Abstract
The production of IgE is mainly regulated by cognate and/or non-cognate interaction between B cells and T cells. Two types of helper T cells are recognized in the murine system, Th1 and Th2, by the type of cytokine they produce. Several lines of evidence disclosed that unbalanced generation of Th2 Th1-like cells occurs in atopic disorders, such as atopic dermatitis, in which a high level of serum IgE is found in the majority of patients. Analysis of skin-derived immunocompetent cells, such as Langerhans cells and T cells, has provided us with a new understanding of the pathophysiology of atopic dermatitis. The recent progress in immunological aspects of atopic dermatitis is reviewed.
Original language | English |
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Pages (from-to) | 159-168 |
Number of pages | 10 |
Journal | Journal of Dermatological Science |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 1994 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
- Dermatology