ATP as a neurotransmitter in the brain: Its possibility based upon recent findings

K. Nakazawa, S. Koizumi, Kazuhide Inoue

Research output: Contribution to journalReview article

Abstract

We discuss here possible neurotransmitter roles of extracellular ATP in the central nervous system. Important findings concerning the effects of ATP on central neurons have been made in the last few years. A fast neurotransmitter role of ATP in rat medial habenula reported by Edwards et al. (1992) may be the best example. In rat cultured hippocampal neurons, we have found that ATP evokes postsynaptic currents, and increases the intracellular Ca2+ concentration. In addition, ATP also produces a 'long-term potentiation life effect' in these cells. Receptors for ATP are generally divided into two classes: one class is coupled with ion channels and the other class is coupled with GTP-binding proteins. In cultured hippocampal neurons, the GTP-binding protein-coupled receptors are present and promote the inhibition of K+ channels. Although the channel-coupled receptors have not been identified in the hippocampal neurons, these channels have been found in nucleus solitarii and locus coeruleus. Several types of ATP receptors have been cloned very recently. These cloned receptors, combined with molecular biological techniques, will allow great progress in this field.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJapanese Journal of Psychopharmacology
Volume15
Issue number1
Publication statusPublished - 1995
Externally publishedYes

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Neurotransmitter Agents
Adenosine Triphosphate
Brain
Purinergic P2 Receptors
Neurons
GTP-Binding Proteins
Habenula
Synaptic Potentials
Solitary Nucleus
Locus Coeruleus
Long-Term Potentiation
Ion Channels
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

ATP as a neurotransmitter in the brain : Its possibility based upon recent findings. / Nakazawa, K.; Koizumi, S.; Inoue, Kazuhide.

In: Japanese Journal of Psychopharmacology, Vol. 15, No. 1, 1995, p. 1-11.

Research output: Contribution to journalReview article

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