ATP receptors for the protection of hippocampal functions

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The inhibitory effects of extracellular adenosine 5'-triphosphate (ATP) are reviewed in the present paper. ATP inhibits the release of the excitatory transmitter glutamate and stimulates the release of the inhibitory transmitter GABA from hippocampal neurons. Also, ATP activates potassium conductance directly through G protein, resulting in hyperpolarization of membrane potential. ATP activates microglia to secrete plasminogen that promotes the development of mesencephalic dopaminergic neurons and enhances neurite outgrowth from explants of neocortical tissue. Moreover, ATP may protect hippocampal neurons from excitotoxic cell death by preserving mitochondrial function. Thus, ATP may have a role in the protection of the function of hippocampus from over-stimulation by glutamate.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalJapanese Journal of Pharmacology
Volume78
Issue number4
DOIs
Publication statusPublished - Dec 1998
Externally publishedYes

Fingerprint

Adenosine Triphosphate
Glutamic Acid
GABAergic Neurons
Plasminogen
Dopaminergic Neurons
Microglia
GTP-Binding Proteins
Membrane Potentials
Hippocampus
Potassium
Cell Death
Neurons

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Molecular Medicine

Cite this

ATP receptors for the protection of hippocampal functions. / Inoue, Kazuhide.

In: Japanese Journal of Pharmacology, Vol. 78, No. 4, 12.1998, p. 405-410.

Research output: Contribution to journalReview article

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