ATP receptors in pain sensation

Kazuhide Inoue, Tsuda Makoto, Schuichi Koizumi

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

We reported that activation of P2X2/3 heteromeric channels in Aδ-DRG neurons causes tactile allodynia and activation of P2X3 in C-fiber causes nocifensive behavior. We also found that tactile allodynia under the chronic pain state requires an activation of P2X4 ionotropic ATP receptor and p38 mitogen-activated protein kinase in spinal microglia.

Original languageEnglish
Pages (from-to)228-233
Number of pages6
JournalFolia Pharmacologica Japonica
Volume124
Issue number4
DOIs
Publication statusPublished - Nov 8 2004

Fingerprint

Purinergic P2 Receptors
Hyperalgesia
Pain
Unmyelinated Nerve Fibers
Diagnosis-Related Groups
Microglia
p38 Mitogen-Activated Protein Kinases
Chronic Pain
Neurons

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

ATP receptors in pain sensation. / Inoue, Kazuhide; Makoto, Tsuda; Koizumi, Schuichi.

In: Folia Pharmacologica Japonica, Vol. 124, No. 4, 08.11.2004, p. 228-233.

Research output: Contribution to journalReview article

Inoue, Kazuhide ; Makoto, Tsuda ; Koizumi, Schuichi. / ATP receptors in pain sensation. In: Folia Pharmacologica Japonica. 2004 ; Vol. 124, No. 4. pp. 228-233.
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