ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor-induced coronary vasodilation in dogs

Yousuke Katsuda, Kensuke Egashira, Hideki Ueno, Yukinori Arai, Yutaka Akatsuka, Takeshi Kuga, Hiroaki Shimokawa, Akira Takeshita

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The opening of ATP-sensitive K+ (KATP+) channels contributes to the mechanism of metabolic coronary vasodilation. The aim of the present study was to determine whether KATP+ channel opener pinacidil augments coronary vasodilation induced by β-adrenoceptor stimulation. In anesthetized dogs, coronary vasodilation in response to intracoronary infusion of a β1-adrenoceptor agonist denopamine, selective β2-adrenoceptor stimulation with isoproterenol after bisoprolol or nitroglycerin was studied before and during simultaneous intracoronary infusion of pinacidil at a dose of 1 μg/min, which had no effect on basal hemodynamics. Pinacidil augmented the denopamine-induced increase in coronary blood flow (CBF) from 38 ± 9 to 66 ± 16% (P < 0.05) but did not affect the denopamine-induced increase in myocardial oxygen consumption (MV̇O2). Pinacidil had no effect on the increases in CBF or MV̇O2 induced by isoproterenol or nitroglycerin. Thus pinacidil selectively augmented β1-adrenoceptor-mediated coronary vasodilation. These observations suggest that the KATP+, channel opener pinacidil may increase myocardial perfusion during metabolic stress associated with β1-adrenoceptor stimulation.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume39
Issue number6
Publication statusPublished - Jun 1996

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Pinacidil
Vasodilation
Adrenergic Receptors
Adenosine Triphosphate
Dogs
KATP Channels
Nitroglycerin
Isoproterenol
Bisoprolol
Physiological Stress
Oxygen Consumption
Perfusion
Hemodynamics
denopamine

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor-induced coronary vasodilation in dogs. / Katsuda, Yousuke; Egashira, Kensuke; Ueno, Hideki; Arai, Yukinori; Akatsuka, Yutaka; Kuga, Takeshi; Shimokawa, Hiroaki; Takeshita, Akira.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 39, No. 6, 06.1996.

Research output: Contribution to journalArticle

Katsuda, Yousuke ; Egashira, Kensuke ; Ueno, Hideki ; Arai, Yukinori ; Akatsuka, Yutaka ; Kuga, Takeshi ; Shimokawa, Hiroaki ; Takeshita, Akira. / ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor-induced coronary vasodilation in dogs. In: American Journal of Physiology - Heart and Circulatory Physiology. 1996 ; Vol. 39, No. 6.
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