ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia

Hisao Taguchi, Donald D. Heistad, Takanari Kitazono, Frank M. Faraci

Research output: Contribution to journalArticle

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Abstract

We tested the hypothesis that dilatation of cerebral arterioles during hypoxia is mediated by activation of ATP-sensitive K+ channels. The diameter of pial arterioles was measured through a closed cranial window in anesthetized rabbits. Topical application of aprikalim (10-6 mol/L), a direct activator of ATP-sensitive K+ channels, dilated pial arterioles by 18±3% (mean±SEM). Glibenclamide (10-6 mol/L), an inhibitor of ATP- sensitive K+ channels, virtually abolished aprikalim-induced vasodilatation. When arterial PO2 was reduced from 129±3 to 25±1 mm Hg, the diameter of cerebral arterioles increased by 66±9% (P<.05). Glibenclamide inhibited dilatation of pial arterioles during hypoxia by 46±5% (P<.05). In contrast, vasodilatation in response to sodium nitroprusside was not altered by glibenclamide. Topical application of adenosine (10-4 mol/L) increased arteriolar diameter by 21±4%. Glibenclamide did not affect adenosine- induced vasodilatation. These findings suggest that dilatation of cerebral arterioles in response to hypoxia is mediated, in part, by activation of ATP- sensitive K+ channels.

Original languageEnglish
Pages (from-to)1005-1008
Number of pages4
JournalCirculation research
Volume74
Issue number5
DOIs
Publication statusPublished - May 1994

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Arterioles
Dilatation
Glyburide
Adenosine Triphosphate
Vasodilation
Adenosine
Nitroprusside
Hypoxia
Rabbits

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. / Taguchi, Hisao; Heistad, Donald D.; Kitazono, Takanari; Faraci, Frank M.

In: Circulation research, Vol. 74, No. 5, 05.1994, p. 1005-1008.

Research output: Contribution to journalArticle

Taguchi, Hisao ; Heistad, Donald D. ; Kitazono, Takanari ; Faraci, Frank M. / ATP-sensitive K+ channels mediate dilatation of cerebral arterioles during hypoxia. In: Circulation research. 1994 ; Vol. 74, No. 5. pp. 1005-1008.
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