ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Kennichi Nagai, Mamoru Uemura, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

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10 Citations (Scopus)

Abstract

The adenosine triphosphate-binding cassette transporter-homologous gene ATP11A belongs to an extended family of adenosine triphosphate-binding cassette transporters. We analysed the ATP11A gene in 7 colorectal cancer cell lines and 95 paired cases of colorectal cancer and non-cancerous regions to demonstrate the importance of ATP11A expression in colorectal cancer prognosis. ATP11A was expressed in the 7 colorectal cancer cell lines. ATP11A mRNA expression was higher in colorectal cancer tissue than in corresponding normal tissue (P<0.001). Patients with high ATP11A expression showed a poorer disease-free survival rate compared to those with low expression (P<0.001), thus indicating that increase in ATP11A expression was an independent predictor of metachronous metastasis of colorectal cancer. The present study suggests that ATP11A is a useful predictive marker of metastasis in colorectal cancer patients.

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalOncology Reports
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Miyoshi, N., Ishii, H., Mimori, K., Tanaka, F., Nagai, K., Uemura, M., Sekimoto, M., Doki, Y., & Mori, M. (2010). ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. Oncology Reports, 23(2), 505-510. https://doi.org/10.3892/or-00000662