ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer

Norikatsu Miyoshi, Hideshi Ishii, Koshi Mimori, Fumiaki Tanaka, Kennichi Nagai, Mamoru Uemura, Mitsugu Sekimoto, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The adenosine triphosphate-binding cassette transporter-homologous gene ATP11A belongs to an extended family of adenosine triphosphate-binding cassette transporters. We analysed the ATP11A gene in 7 colorectal cancer cell lines and 95 paired cases of colorectal cancer and non-cancerous regions to demonstrate the importance of ATP11A expression in colorectal cancer prognosis. ATP11A was expressed in the 7 colorectal cancer cell lines. ATP11A mRNA expression was higher in colorectal cancer tissue than in corresponding normal tissue (P<0.001). Patients with high ATP11A expression showed a poorer disease-free survival rate compared to those with low expression (P<0.001), thus indicating that increase in ATP11A expression was an independent predictor of metachronous metastasis of colorectal cancer. The present study suggests that ATP11A is a useful predictive marker of metastasis in colorectal cancer patients.

Original languageEnglish
Pages (from-to)505-510
Number of pages6
JournalOncology Reports
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 1 2010

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Colorectal Neoplasms
Neoplasm Metastasis
Adenosine Triphosphate
Cell Line
Genes
Disease-Free Survival
Survival Rate
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. / Miyoshi, Norikatsu; Ishii, Hideshi; Mimori, Koshi; Tanaka, Fumiaki; Nagai, Kennichi; Uemura, Mamoru; Sekimoto, Mitsugu; Doki, Yuichiro; Mori, Masaki.

In: Oncology Reports, Vol. 23, No. 2, 01.02.2010, p. 505-510.

Research output: Contribution to journalArticle

Miyoshi, N, Ishii, H, Mimori, K, Tanaka, F, Nagai, K, Uemura, M, Sekimoto, M, Doki, Y & Mori, M 2010, 'ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer', Oncology Reports, vol. 23, no. 2, pp. 505-510. https://doi.org/10.3892/or-00000662
Miyoshi, Norikatsu ; Ishii, Hideshi ; Mimori, Koshi ; Tanaka, Fumiaki ; Nagai, Kennichi ; Uemura, Mamoru ; Sekimoto, Mitsugu ; Doki, Yuichiro ; Mori, Masaki. / ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer. In: Oncology Reports. 2010 ; Vol. 23, No. 2. pp. 505-510.
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