Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population

Takehiro Torisu, Takayuki Matsumoto, Yutaka Takata, Toshihiro Ansai, Inho Soh, Shuji Awano, Ikuo Nakamichi, Shuntaro Kagiyama, Kazuo Sonoki, Akihiro Yoshida, Tomoko Hamasaki, Mitsuo Iida, Tadamichi Takehara

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Abstract

Background: The relationship between Helicobacter pylori (HP) infection and body mass index (BMI) is controversial. Several reports have indicated that eradication of HP infection induces an increase in BMI. In contrast, epidemiological case-control studies have failed to show an association between HP infection and BMI. Therefore, we investigated whether HP and atrophic gastritis (AG) were associated with BMI. Methods: A total of 617 individuals were recruited for the measurements of BMI, serum leptin, pepsinogens (PGs) I and II, and IgG antibody to HP (HP-IgG). BMI and leptin of the subjects were compared when the subjects were stratified by HP-IgG and PGs. Results: The subjects were divided into AG-positive and AG-negative groups according to PGs (AG-positive: PG I ≤ 70 ng/ml and PG I/II ratio ≤ 3.0). BMI after adjusting for sex and age was significantly lower in the AG-positive group than in the AG-negative group (23.47 ± 3.05 vs. 24.18 ± 3.25, P = 0.010). When the subjects were divided into two groups according to HP-IgG, BMI tended to be lower in the HP-IgG-positive group, though the difference was not large. When the subjects were divided into four groups for different combinations of AG and HP-IgG, BMI was the lowest in the AG-positive and HP-IgG-negative group. Conclusions: BMI was associated with AG, as diagnosed by PGs, but not with HP infection status. These results mean that HP infection affects BMI via atrophic gastritis.

Original languageEnglish
Pages (from-to)762-766
Number of pages5
JournalJournal of gastroenterology
Volume43
Issue number10
DOIs
Publication statusPublished - Nov 10 2008

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Atrophic Gastritis
Helicobacter pylori
Body Mass Index
Antibodies
Population
Helicobacter Infections
Immunoglobulin G
Pepsinogens
Pepsinogen A
Pepsinogen C
Leptin
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population. / Torisu, Takehiro; Matsumoto, Takayuki; Takata, Yutaka; Ansai, Toshihiro; Soh, Inho; Awano, Shuji; Nakamichi, Ikuo; Kagiyama, Shuntaro; Sonoki, Kazuo; Yoshida, Akihiro; Hamasaki, Tomoko; Iida, Mitsuo; Takehara, Tadamichi.

In: Journal of gastroenterology, Vol. 43, No. 10, 10.11.2008, p. 762-766.

Research output: Contribution to journalArticle

Torisu, T, Matsumoto, T, Takata, Y, Ansai, T, Soh, I, Awano, S, Nakamichi, I, Kagiyama, S, Sonoki, K, Yoshida, A, Hamasaki, T, Iida, M & Takehara, T 2008, 'Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population', Journal of gastroenterology, vol. 43, no. 10, pp. 762-766. https://doi.org/10.1007/s00535-008-2219-0
Torisu, Takehiro ; Matsumoto, Takayuki ; Takata, Yutaka ; Ansai, Toshihiro ; Soh, Inho ; Awano, Shuji ; Nakamichi, Ikuo ; Kagiyama, Shuntaro ; Sonoki, Kazuo ; Yoshida, Akihiro ; Hamasaki, Tomoko ; Iida, Mitsuo ; Takehara, Tadamichi. / Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population. In: Journal of gastroenterology. 2008 ; Vol. 43, No. 10. pp. 762-766.
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abstract = "Background: The relationship between Helicobacter pylori (HP) infection and body mass index (BMI) is controversial. Several reports have indicated that eradication of HP infection induces an increase in BMI. In contrast, epidemiological case-control studies have failed to show an association between HP infection and BMI. Therefore, we investigated whether HP and atrophic gastritis (AG) were associated with BMI. Methods: A total of 617 individuals were recruited for the measurements of BMI, serum leptin, pepsinogens (PGs) I and II, and IgG antibody to HP (HP-IgG). BMI and leptin of the subjects were compared when the subjects were stratified by HP-IgG and PGs. Results: The subjects were divided into AG-positive and AG-negative groups according to PGs (AG-positive: PG I ≤ 70 ng/ml and PG I/II ratio ≤ 3.0). BMI after adjusting for sex and age was significantly lower in the AG-positive group than in the AG-negative group (23.47 ± 3.05 vs. 24.18 ± 3.25, P = 0.010). When the subjects were divided into two groups according to HP-IgG, BMI tended to be lower in the HP-IgG-positive group, though the difference was not large. When the subjects were divided into four groups for different combinations of AG and HP-IgG, BMI was the lowest in the AG-positive and HP-IgG-negative group. Conclusions: BMI was associated with AG, as diagnosed by PGs, but not with HP infection status. These results mean that HP infection affects BMI via atrophic gastritis.",
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T1 - Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population

AU - Torisu, Takehiro

AU - Matsumoto, Takayuki

AU - Takata, Yutaka

AU - Ansai, Toshihiro

AU - Soh, Inho

AU - Awano, Shuji

AU - Nakamichi, Ikuo

AU - Kagiyama, Shuntaro

AU - Sonoki, Kazuo

AU - Yoshida, Akihiro

AU - Hamasaki, Tomoko

AU - Iida, Mitsuo

AU - Takehara, Tadamichi

PY - 2008/11/10

Y1 - 2008/11/10

N2 - Background: The relationship between Helicobacter pylori (HP) infection and body mass index (BMI) is controversial. Several reports have indicated that eradication of HP infection induces an increase in BMI. In contrast, epidemiological case-control studies have failed to show an association between HP infection and BMI. Therefore, we investigated whether HP and atrophic gastritis (AG) were associated with BMI. Methods: A total of 617 individuals were recruited for the measurements of BMI, serum leptin, pepsinogens (PGs) I and II, and IgG antibody to HP (HP-IgG). BMI and leptin of the subjects were compared when the subjects were stratified by HP-IgG and PGs. Results: The subjects were divided into AG-positive and AG-negative groups according to PGs (AG-positive: PG I ≤ 70 ng/ml and PG I/II ratio ≤ 3.0). BMI after adjusting for sex and age was significantly lower in the AG-positive group than in the AG-negative group (23.47 ± 3.05 vs. 24.18 ± 3.25, P = 0.010). When the subjects were divided into two groups according to HP-IgG, BMI tended to be lower in the HP-IgG-positive group, though the difference was not large. When the subjects were divided into four groups for different combinations of AG and HP-IgG, BMI was the lowest in the AG-positive and HP-IgG-negative group. Conclusions: BMI was associated with AG, as diagnosed by PGs, but not with HP infection status. These results mean that HP infection affects BMI via atrophic gastritis.

AB - Background: The relationship between Helicobacter pylori (HP) infection and body mass index (BMI) is controversial. Several reports have indicated that eradication of HP infection induces an increase in BMI. In contrast, epidemiological case-control studies have failed to show an association between HP infection and BMI. Therefore, we investigated whether HP and atrophic gastritis (AG) were associated with BMI. Methods: A total of 617 individuals were recruited for the measurements of BMI, serum leptin, pepsinogens (PGs) I and II, and IgG antibody to HP (HP-IgG). BMI and leptin of the subjects were compared when the subjects were stratified by HP-IgG and PGs. Results: The subjects were divided into AG-positive and AG-negative groups according to PGs (AG-positive: PG I ≤ 70 ng/ml and PG I/II ratio ≤ 3.0). BMI after adjusting for sex and age was significantly lower in the AG-positive group than in the AG-negative group (23.47 ± 3.05 vs. 24.18 ± 3.25, P = 0.010). When the subjects were divided into two groups according to HP-IgG, BMI tended to be lower in the HP-IgG-positive group, though the difference was not large. When the subjects were divided into four groups for different combinations of AG and HP-IgG, BMI was the lowest in the AG-positive and HP-IgG-negative group. Conclusions: BMI was associated with AG, as diagnosed by PGs, but not with HP infection status. These results mean that HP infection affects BMI via atrophic gastritis.

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