Attachment and growth of fibroblast cells on poly (2-methoxyethyl acrylate) analog polymers as coating materials

Rubaiya Anjum, Kei Nishida, Haruka Matsumoto, Daiki Murakami, Shingo Kobayashi, Takahisa Anada, Masaru Tanaka

Research output: Contribution to journalArticlepeer-review

Abstract

The regulation of adhesion and the subsequent behavior of fibroblast cells on the surface of biomaterials is important for successful tissue regeneration and wound healing by implanted biomaterials. We have synthesized poly(ω-methoxyalkyl acrylate)s (PMCxAs; x indicates the number of methylene carbons between the ester and ethyl oxygen), with a carbon chain length of x = 2–6, to investigate the regulation of fibroblast cell behavior including adhesion, proliferation, migration, differentiation and collagen production. We found that PMC2A suppressed the cell spreading, protein adsorption, formation of focal adhesion, and differentiation of normal human dermal fibroblasts, while PMC4A surfaces enhanced them compared to other PMCxAs. Our findings suggest that fibroblast activities attached to the PMCxA substrates can be modified by changing the number of methylene carbons in the side chains of the polymers. These results indicate that PMCxAs could be useful coating materials for use in skin regeneration and wound dressing applications.

Original languageEnglish
Article number461
JournalCoatings
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2021

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

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