Abstract
Introduction: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction. Methods: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a double-blind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed. Thirty-five participants completed resting-state functional magnetic resonance imaging (MRI) scans before and after training. Results: ABM significantly mitigated an anxious traits regarding physical stress vulnerability (η2 = 0.12, p = 0.009). As compared to sham training, ABM significantly strengthened FC between the pulvinar and transverse gyrus along the temporoparietal junction (T = 3.90, FDR-corrected p = 0.010), whereas it decreased FC between the postCG and ventral fronto-parietal network (vFPN) regions such as the anterior insula and ventrolateral prefrontal cortex (all T ≤ − 3.19, FDR-corrected p ≤ 0.034). Although ABM diminished network measures of the postcentral gyrus (postCG) (all T ≤ − 4.30, FDR-corrected p ≤ 0.006), only the pulvinar-related FC increase was specifically correlated with anxiety reduction (r = − 0.46, p = 0.007). Limitations: Per-protocol analysis and reduced sample size in MRI analysis. Conclusions: ABM might augment the pulvinar's control over vFPN to maintain endogenous attention to a behavioral goal, while diminishing the information exchanges of the postCG with vFPN to inhibit the capture of exogenous attention by potential threats. The pulvinar might play a critical role in ABM anxiolytic efficacy.
| Original language | English |
|---|---|
| Pages (from-to) | 472-481 |
| Number of pages | 10 |
| Journal | Journal of Affective Disorders |
| Volume | 238 |
| DOIs | |
| Publication status | Published - Oct 1 2018 |
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All Science Journal Classification (ASJC) codes
- Clinical Psychology
- Psychiatry and Mental health
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Attentional bias modification alters intrinsic functional network of attentional control : A randomized controlled trial. / Hakamata, Yuko; Mizukami, Shinya; Komi, Shotaro; Sato, Eisuke; Moriguchi, Yoshiya; motomura, Yuki; Maruo, Kazushi; Izawa, Shuhei; Kim, Yoshiharu; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni.
In: Journal of Affective Disorders, Vol. 238, 01.10.2018, p. 472-481.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Attentional bias modification alters intrinsic functional network of attentional control
T2 - A randomized controlled trial
AU - Hakamata, Yuko
AU - Mizukami, Shinya
AU - Komi, Shotaro
AU - Sato, Eisuke
AU - Moriguchi, Yoshiya
AU - motomura, Yuki
AU - Maruo, Kazushi
AU - Izawa, Shuhei
AU - Kim, Yoshiharu
AU - Hanakawa, Takashi
AU - Inoue, Yusuke
AU - Tagaya, Hirokuni
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Introduction: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction. Methods: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a double-blind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed. Thirty-five participants completed resting-state functional magnetic resonance imaging (MRI) scans before and after training. Results: ABM significantly mitigated an anxious traits regarding physical stress vulnerability (η2 = 0.12, p = 0.009). As compared to sham training, ABM significantly strengthened FC between the pulvinar and transverse gyrus along the temporoparietal junction (T = 3.90, FDR-corrected p = 0.010), whereas it decreased FC between the postCG and ventral fronto-parietal network (vFPN) regions such as the anterior insula and ventrolateral prefrontal cortex (all T ≤ − 3.19, FDR-corrected p ≤ 0.034). Although ABM diminished network measures of the postcentral gyrus (postCG) (all T ≤ − 4.30, FDR-corrected p ≤ 0.006), only the pulvinar-related FC increase was specifically correlated with anxiety reduction (r = − 0.46, p = 0.007). Limitations: Per-protocol analysis and reduced sample size in MRI analysis. Conclusions: ABM might augment the pulvinar's control over vFPN to maintain endogenous attention to a behavioral goal, while diminishing the information exchanges of the postCG with vFPN to inhibit the capture of exogenous attention by potential threats. The pulvinar might play a critical role in ABM anxiolytic efficacy.
AB - Introduction: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction. Methods: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a double-blind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed. Thirty-five participants completed resting-state functional magnetic resonance imaging (MRI) scans before and after training. Results: ABM significantly mitigated an anxious traits regarding physical stress vulnerability (η2 = 0.12, p = 0.009). As compared to sham training, ABM significantly strengthened FC between the pulvinar and transverse gyrus along the temporoparietal junction (T = 3.90, FDR-corrected p = 0.010), whereas it decreased FC between the postCG and ventral fronto-parietal network (vFPN) regions such as the anterior insula and ventrolateral prefrontal cortex (all T ≤ − 3.19, FDR-corrected p ≤ 0.034). Although ABM diminished network measures of the postcentral gyrus (postCG) (all T ≤ − 4.30, FDR-corrected p ≤ 0.006), only the pulvinar-related FC increase was specifically correlated with anxiety reduction (r = − 0.46, p = 0.007). Limitations: Per-protocol analysis and reduced sample size in MRI analysis. Conclusions: ABM might augment the pulvinar's control over vFPN to maintain endogenous attention to a behavioral goal, while diminishing the information exchanges of the postCG with vFPN to inhibit the capture of exogenous attention by potential threats. The pulvinar might play a critical role in ABM anxiolytic efficacy.
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U2 - 10.1016/j.jad.2018.06.018
DO - 10.1016/j.jad.2018.06.018
M3 - Article
VL - 238
SP - 472
EP - 481
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -