Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial

Yuko Hakamata, Shinya Mizukami, Shotaro Komi, Eisuke Sato, Yoshiya Moriguchi, Yuki Motomura, Kazushi Maruo, Shuhei Izawa, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya

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3 Citations (Scopus)

Abstract

Introduction: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction. Methods: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a double-blind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed. Thirty-five participants completed resting-state functional magnetic resonance imaging (MRI) scans before and after training. Results: ABM significantly mitigated an anxious traits regarding physical stress vulnerability (η2 = 0.12, p = 0.009). As compared to sham training, ABM significantly strengthened FC between the pulvinar and transverse gyrus along the temporoparietal junction (T = 3.90, FDR-corrected p = 0.010), whereas it decreased FC between the postCG and ventral fronto-parietal network (vFPN) regions such as the anterior insula and ventrolateral prefrontal cortex (all T ≤ − 3.19, FDR-corrected p ≤ 0.034). Although ABM diminished network measures of the postcentral gyrus (postCG) (all T ≤ − 4.30, FDR-corrected p ≤ 0.006), only the pulvinar-related FC increase was specifically correlated with anxiety reduction (r = − 0.46, p = 0.007). Limitations: Per-protocol analysis and reduced sample size in MRI analysis. Conclusions: ABM might augment the pulvinar's control over vFPN to maintain endogenous attention to a behavioral goal, while diminishing the information exchanges of the postCG with vFPN to inhibit the capture of exogenous attention by potential threats. The pulvinar might play a critical role in ABM anxiolytic efficacy.

Original languageEnglish
Pages (from-to)472-481
Number of pages10
JournalJournal of Affective Disorders
Volume238
DOIs
Publication statusPublished - Oct 1 2018

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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    Hakamata, Y., Mizukami, S., Komi, S., Sato, E., Moriguchi, Y., Motomura, Y., Maruo, K., Izawa, S., Kim, Y., Hanakawa, T., Inoue, Y., & Tagaya, H. (2018). Attentional bias modification alters intrinsic functional network of attentional control: A randomized controlled trial. Journal of Affective Disorders, 238, 472-481. https://doi.org/10.1016/j.jad.2018.06.018