Atypical development of the central auditory system in young children with Autism spectrum disorder

Yuko Yoshimura, Mitsuru Kikuchi, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Gerard Bastiaan Remijn, Manabu Oi, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, Haruyuki Kojima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32–121 months of age) and 35 children with autism spectrum disorder (ASD) (38–111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. Autism Res 2016, 9: 1216–1226.

Original languageEnglish
Pages (from-to)1216-1226
Number of pages11
JournalAutism Research
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Language
Growth
Magnetoencephalography
Age Distribution
Magnetic Fields
Autistic Disorder
Autism Spectrum Disorder
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology
  • Genetics(clinical)

Cite this

Yoshimura, Y., Kikuchi, M., Hiraishi, H., Hasegawa, C., Takahashi, T., Remijn, G. B., ... Kojima, H. (2016). Atypical development of the central auditory system in young children with Autism spectrum disorder. Autism Research, 9(11), 1216-1226. https://doi.org/10.1002/aur.1604

Atypical development of the central auditory system in young children with Autism spectrum disorder. / Yoshimura, Yuko; Kikuchi, Mitsuru; Hiraishi, Hirotoshi; Hasegawa, Chiaki; Takahashi, Tetsuya; Remijn, Gerard Bastiaan; Oi, Manabu; Munesue, Toshio; Higashida, Haruhiro; Minabe, Yoshio; Kojima, Haruyuki.

In: Autism Research, Vol. 9, No. 11, 01.11.2016, p. 1216-1226.

Research output: Contribution to journalArticle

Yoshimura, Y, Kikuchi, M, Hiraishi, H, Hasegawa, C, Takahashi, T, Remijn, GB, Oi, M, Munesue, T, Higashida, H, Minabe, Y & Kojima, H 2016, 'Atypical development of the central auditory system in young children with Autism spectrum disorder', Autism Research, vol. 9, no. 11, pp. 1216-1226. https://doi.org/10.1002/aur.1604
Yoshimura, Yuko ; Kikuchi, Mitsuru ; Hiraishi, Hirotoshi ; Hasegawa, Chiaki ; Takahashi, Tetsuya ; Remijn, Gerard Bastiaan ; Oi, Manabu ; Munesue, Toshio ; Higashida, Haruhiro ; Minabe, Yoshio ; Kojima, Haruyuki. / Atypical development of the central auditory system in young children with Autism spectrum disorder. In: Autism Research. 2016 ; Vol. 9, No. 11. pp. 1216-1226.
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