TY - JOUR
T1 - Atypical glomus tumor arising in the liver
T2 - a case report
AU - Hirose, Katsutoshi
AU - Matsui, Takahiro
AU - Nagano, Hiroaki
AU - Eguchi, Hidetoshi
AU - Marubashi, Shigeru
AU - Wada, Hiroshi
AU - Morii, Eiichi
N1 - Publisher Copyright:
© 2015 Hirose et al.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/7/19
Y1 - 2015/7/19
N2 - Background: Glomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein, a unique case of a liver glomus tumor with atypical histological features is reported. Case presentation: A 39-year-old man felt fullness in the epigastrium, and an enhanced computed tomography (CT) scan of the abdomen and pelvis revealed a 21-cm solid and cystic mass in the left liver lobe. The patient underwent a left hepatic lobectomy, and the tumor was pathologically identified as a glomus tumor with atypical histological features in the liver. This case is unique for three reasons. First, cases of glomus tumors in the liver are extremely rare. Second, this is the first report of a hepatic glomus tumor with histologically atypical features. Third, immunohistochemical staining showed focal positivity for synaptophysin. A literature review revealed that glomus tumors in visceral organs positive for synaptophysin show histological atypical features in most cases. Conclusions: This is the first case of a glomus tumor with atypical histological features arising in the liver. This unique case and literature review yielded interesting findings and enabled us to postulate that synaptophysin positivity may be indicative of atypical histological features in glomus tumors arising in visceral organs.
AB - Background: Glomus tumors typically occur in the subcutaneous tissue of distal extremities, but rarely in visceral organs. Most glomus tumors are benign, while others have been reported to have malignant potential. Herein, a unique case of a liver glomus tumor with atypical histological features is reported. Case presentation: A 39-year-old man felt fullness in the epigastrium, and an enhanced computed tomography (CT) scan of the abdomen and pelvis revealed a 21-cm solid and cystic mass in the left liver lobe. The patient underwent a left hepatic lobectomy, and the tumor was pathologically identified as a glomus tumor with atypical histological features in the liver. This case is unique for three reasons. First, cases of glomus tumors in the liver are extremely rare. Second, this is the first report of a hepatic glomus tumor with histologically atypical features. Third, immunohistochemical staining showed focal positivity for synaptophysin. A literature review revealed that glomus tumors in visceral organs positive for synaptophysin show histological atypical features in most cases. Conclusions: This is the first case of a glomus tumor with atypical histological features arising in the liver. This unique case and literature review yielded interesting findings and enabled us to postulate that synaptophysin positivity may be indicative of atypical histological features in glomus tumors arising in visceral organs.
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U2 - 10.1186/s13000-015-0355-4
DO - 10.1186/s13000-015-0355-4
M3 - Article
C2 - 26187280
AN - SCOPUS:84937539658
VL - 10
JO - Diagnostic Pathology
JF - Diagnostic Pathology
SN - 1746-1596
IS - 1
M1 - 112
ER -