Atypical MDR

A. Yokomizo, K. Taniguchi, S. Hasegawa, T. Abe, T. Kubo, Y. Makino, M. Wada, K. Kohno, M. Kuwano

Research output: Contribution to journalReview article

Abstract

Multiple drug resistance (MDR) is a major clinical obstacle in cancer chemotherapy. Acquirement of MDR phenotype in cancer cells is often associated with enhanced expression of human MDR-1 gene: MDR-1 gene codes membranous P-glycoprotein which catalyses energy-dependent outward transport of anticancer agents. By contrast, MDR cancer cell lines without overexpression of P-glycoprotein are called as atypical MDR (at MDR) cells. The acquirement of at MDR has been shown to be partly associated with altered DNA topoisomerase II. Furthermore, a new ATP binding cassette (ABC) family, MRP gene has just recently shown to involve in acquirement of at-MDR in cancer cell lines, which do not express both altered topoisomerase II and P-glycoprotein.

Original languageEnglish
Pages (from-to)1123-1129
Number of pages7
JournalJapanese Journal of Cancer and Chemotherapy
Volume21
Issue number8
Publication statusPublished - Jan 1 1994

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Multiple Drug Resistance
P-Glycoprotein
Type II DNA Topoisomerase
Neoplasms
Genes
Cell Line
Antineoplastic Agents
Adenosine Triphosphate
Phenotype
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Yokomizo, A., Taniguchi, K., Hasegawa, S., Abe, T., Kubo, T., Makino, Y., ... Kuwano, M. (1994). Atypical MDR. Japanese Journal of Cancer and Chemotherapy, 21(8), 1123-1129.

Atypical MDR. / Yokomizo, A.; Taniguchi, K.; Hasegawa, S.; Abe, T.; Kubo, T.; Makino, Y.; Wada, M.; Kohno, K.; Kuwano, M.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 21, No. 8, 01.01.1994, p. 1123-1129.

Research output: Contribution to journalReview article

Yokomizo, A, Taniguchi, K, Hasegawa, S, Abe, T, Kubo, T, Makino, Y, Wada, M, Kohno, K & Kuwano, M 1994, 'Atypical MDR', Japanese Journal of Cancer and Chemotherapy, vol. 21, no. 8, pp. 1123-1129.
Yokomizo A, Taniguchi K, Hasegawa S, Abe T, Kubo T, Makino Y et al. Atypical MDR. Japanese Journal of Cancer and Chemotherapy. 1994 Jan 1;21(8):1123-1129.
Yokomizo, A. ; Taniguchi, K. ; Hasegawa, S. ; Abe, T. ; Kubo, T. ; Makino, Y. ; Wada, M. ; Kohno, K. ; Kuwano, M. / Atypical MDR. In: Japanese Journal of Cancer and Chemotherapy. 1994 ; Vol. 21, No. 8. pp. 1123-1129.
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