TY - JOUR
T1 - Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia
AU - Hirano, Yoji
AU - Oribe, Naoya
AU - Onitsuka, Toshiaki
AU - Kanba, Shigenobu
AU - Nestor, Paul G.
AU - Hosokawa, Taiga
AU - Levin, Margaret
AU - Shenton, Martha E.
AU - McCarley, Robert W.
AU - Spencer, Kevin M.
N1 - Funding Information:
We investigated whether the gray matter volume of primary auditory cortex (Heschl’s gyrus [HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely impaired γ synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband γ power. (The γ data were previously reported in Hirano et al, JAMA Psychiatry , 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz rates. Dipole source localization of the ASSR was used to provide a spatial filter of auditory cortex activity, from which ASSR evoked power and phase locking factor (PLF), and induced γ power were computed. HG gray matter volume was derived from structural magnetic resonance imaging at 3 T with manually traced regions of interest. As expected, HG gray matter volume was reduced in SZ compared with HC. In SZ, left hemisphere ASSR PLF and induced γ power during the 40-Hz stimulation condition were positively and negatively correlated with left HG gray matter volume, respectively. These results provide evidence that cortical gray matter structure, possibly resulting from reduced synaptic connectivity at the microcircuit level, is related to impaired γ synchronization and increased spontaneous γ activity in schizophrenia. electroencephalogram (EEG) schizophrenia MRI gamma oscillation auditory cortex SENSHIN Medical Research Foundation https://doi.org/10.13039/501100008667 Fund for Pharmacopsychiatry Research Brain and Behavior Research Foundation https://doi.org/10.13039/100000874 Independent Investigator Award national institutes of health https://doi.org/10.13039/100000002 P50 MH080272 u.s. department of veterans affairs https://doi.org/10.13039/100000738 I01 CX000154 Japan Society for the Promotion of Science https://doi.org/10.13039/501100001691 Grant-in-Aid for Young Scientists B 22791129 Japan Society for the Promotion of Science https://doi.org/10.13039/501100001691 Strategic Young Researcher Overseas Visits Program edited-state corrected-proof typesetter ts1
PY - 2020/7/1
Y1 - 2020/7/1
N2 - We investigated whether the gray matter volume of primary auditory cortex (Heschl’s gyrus [HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely impaired γ synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband γ power. (The γ data were previously reported in Hirano et al, JAMA Psychiatry, 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz rates. Dipole source localization of the ASSR was used to provide a spatial filter of auditory cortex activity, from which ASSR evoked power and phase locking factor (PLF), and induced γ power were computed. HG gray matter volume was derived from structural magnetic resonance imaging at 3 T with manually traced regions of interest. As expected, HG gray matter volume was reduced in SZ compared with HC. In SZ, left hemisphere ASSR PLF and induced γ power during the 40-Hz stimulation condition were positively and negatively correlated with left HG gray matter volume, respectively. These results provide evidence that cortical gray matter structure, possibly resulting from reduced synaptic connectivity at the microcircuit level, is related to impaired γ synchronization and increased spontaneous γ activity in schizophrenia.
AB - We investigated whether the gray matter volume of primary auditory cortex (Heschl’s gyrus [HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely impaired γ synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband γ power. (The γ data were previously reported in Hirano et al, JAMA Psychiatry, 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz rates. Dipole source localization of the ASSR was used to provide a spatial filter of auditory cortex activity, from which ASSR evoked power and phase locking factor (PLF), and induced γ power were computed. HG gray matter volume was derived from structural magnetic resonance imaging at 3 T with manually traced regions of interest. As expected, HG gray matter volume was reduced in SZ compared with HC. In SZ, left hemisphere ASSR PLF and induced γ power during the 40-Hz stimulation condition were positively and negatively correlated with left HG gray matter volume, respectively. These results provide evidence that cortical gray matter structure, possibly resulting from reduced synaptic connectivity at the microcircuit level, is related to impaired γ synchronization and increased spontaneous γ activity in schizophrenia.
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U2 - 10.1177/1550059420914201
DO - 10.1177/1550059420914201
M3 - Article
C2 - 32204613
AN - SCOPUS:85082819518
VL - 51
SP - 244
EP - 251
JO - Clinical EEG and Neuroscience
JF - Clinical EEG and Neuroscience
SN - 1550-0594
IS - 4
ER -