Auditory P50 obtained with a repetitive stimulus paradigm shows suppression to high-intensity tones

Hideaki Ninomiya, Eigo Sato, Toshiaki Onitsuka, Takaharu Hayashida, Nobutada Tashiro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We manipulated stimulus intensity and number of frequency bands in auditory stimuli in order to investigate the nature of P50 in human auditory evoked potentials. Pure-tone and mixed-tone conditions were examined. For each condition, four stimulus intensities were used: 55, 70, 85 and 100 dB sound pressure level (SPL). The P50s were obtained at Cz using a repetitive stimulus paradigm. P50 amplitudes increased as stimulus intensities increased up to 85 dB; with 100 dB stimulation amplitudes decreased. The number of frequency bands in the stimulus did not affect P50 amplitude. Considered in terms of P50 suppression under a conditioning/testing paradigm, the results suggest that the P50 wave reflects activity of the sensory gating mechanism in humans.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalPsychiatry and clinical neurosciences
Volume54
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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