Auditory P50 obtained with a repetitive stimulus paradigm shows suppression to high-intensity tones

Hideaki Ninomiya, Eigo Sato, Toshiaki Onitsuka, Takaharu Hayashida, Nobutada Tashiro

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We manipulated stimulus intensity and number of frequency bands in auditory stimuli in order to investigate the nature of P50 in human auditory evoked potentials. Pure-tone and mixed-tone conditions were examined. For each condition, four stimulus intensities were used: 55, 70, 85 and 100 dB sound pressure level (SPL). The P50s were obtained at Cz using a repetitive stimulus paradigm. P50 amplitudes increased as stimulus intensities increased up to 85 dB; with 100 dB stimulation amplitudes decreased. The number of frequency bands in the stimulus did not affect P50 amplitude. Considered in terms of P50 suppression under a conditioning/testing paradigm, the results suggest that the P50 wave reflects activity of the sensory gating mechanism in humans.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalPsychiatry and Clinical Neurosciences
Volume54
Issue number4
DOIs
Publication statusPublished - Sep 26 2000

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Sensory Gating
Auditory Evoked Potentials
Evoked Potentials
Pressure

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Auditory P50 obtained with a repetitive stimulus paradigm shows suppression to high-intensity tones. / Ninomiya, Hideaki; Sato, Eigo; Onitsuka, Toshiaki; Hayashida, Takaharu; Tashiro, Nobutada.

In: Psychiatry and Clinical Neurosciences, Vol. 54, No. 4, 26.09.2000, p. 493-497.

Research output: Contribution to journalArticle

Ninomiya, Hideaki ; Sato, Eigo ; Onitsuka, Toshiaki ; Hayashida, Takaharu ; Tashiro, Nobutada. / Auditory P50 obtained with a repetitive stimulus paradigm shows suppression to high-intensity tones. In: Psychiatry and Clinical Neurosciences. 2000 ; Vol. 54, No. 4. pp. 493-497.
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