Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei

K. Nomoto, S. Miake, S. Hashimoto, T. Yokokura, M. Mutai, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    The effect of heat-killed Lactobacillus casei YIT 9018 (LC 9018), a potent antitumor agent as well as a potent macrophage-activating agent, on the resistance of mice to Listeria monocytogenes was studied. Mice pretreated intravenously (i.v.) with 0.5 mg of LC 9018 showed enhanced resistance to subsequent i.v. infection with L. monocytogenes. Antigenic cross-reaction between L. monocytogenes and LC 9018 was not seen in the delayed footpad reaction in mice, and LC 9018 inhibited the growth of L. monocytogenes in the liver and spleen of athymic nude mice. Therefore the antilisterial activity of LC 9018 was considered to be expressed non-specifically and independently of the thymus. Carrageenan, a selective macrophage blocker, diminished the antilisterial effect of LC 9018. Peritoneal cells induced by intraperitoneal administration of LC 9018, which were composed mainly of macrophages and polymorphonuclear cells, showed enhanced phagocytosis and marked intracellular killing activity against L. monocytogenes in vitro as compared with those of the control. Kupffer cells of mice pretreated i.v. with LC 9018 produced a high oxygen radical level. The antilisterial effect of LC 9018 was maintained even at 21 days after its injection.

    Original languageEnglish
    Pages (from-to)91-97
    Number of pages7
    JournalJournal of Clinical and Laboratory Immunology
    Volume17
    Issue number2
    Publication statusPublished - Nov 6 1985

    Fingerprint

    Lactobacillus casei
    Listeriosis
    Listeria monocytogenes
    Macrophages
    Nude Mice
    YIT 9018
    Kupffer Cells
    Carrageenan
    Cross Reactions
    Phagocytosis
    Antineoplastic Agents
    Thymus Gland
    Reactive Oxygen Species
    Spleen
    Hot Temperature
    Injections

    All Science Journal Classification (ASJC) codes

    • Immunology

    Cite this

    Nomoto, K., Miake, S., Hashimoto, S., Yokokura, T., Mutai, M., & Yoshikai, Y. (1985). Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei. Journal of Clinical and Laboratory Immunology, 17(2), 91-97.

    Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei. / Nomoto, K.; Miake, S.; Hashimoto, S.; Yokokura, T.; Mutai, M.; Yoshikai, Yasunobu.

    In: Journal of Clinical and Laboratory Immunology, Vol. 17, No. 2, 06.11.1985, p. 91-97.

    Research output: Contribution to journalArticle

    Nomoto, K, Miake, S, Hashimoto, S, Yokokura, T, Mutai, M & Yoshikai, Y 1985, 'Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei', Journal of Clinical and Laboratory Immunology, vol. 17, no. 2, pp. 91-97.
    Nomoto K, Miake S, Hashimoto S, Yokokura T, Mutai M, Yoshikai Y. Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei. Journal of Clinical and Laboratory Immunology. 1985 Nov 6;17(2):91-97.
    Nomoto, K. ; Miake, S. ; Hashimoto, S. ; Yokokura, T. ; Mutai, M. ; Yoshikai, Yasunobu. / Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei. In: Journal of Clinical and Laboratory Immunology. 1985 ; Vol. 17, No. 2. pp. 91-97.
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