TY - JOUR
T1 - Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901
AU - Tanaka, Makoto
AU - Miyazaki, Hiroyuki
AU - Takeda, Yasuyuki
AU - Takeo, Suguru
AU - Yoshikai, Yasunobu
AU - Nomoto, Kikuo
PY - 1992/1/1
Y1 - 1992/1/1
N2 - The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.
AB - The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.
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U2 - 10.3109/08923979209005401
DO - 10.3109/08923979209005401
M3 - Article
C2 - 1517528
AN - SCOPUS:0026667211
VL - 14
SP - 403
EP - 420
JO - Immunopharmacology and Immunotoxicology
JF - Immunopharmacology and Immunotoxicology
SN - 0892-3973
IS - 3
ER -