Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901

Makoto Tanaka, Hiroyuki Miyazaki, Yasuyuki Takeda, Suguru Takeo, Yasunobu Yoshikai, Kikuo Nomoto

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.

    Original languageEnglish
    Pages (from-to)403-420
    Number of pages18
    JournalImmunopharmacology and Immunotoxicology
    Volume14
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 1992

    Fingerprint

    Mitogens
    Interleukin-2
    Polysaccharides
    Oral Administration
    Glucans
    Concanavalin A
    Macrophages
    Dextrans
    rice bran saccharide

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Toxicology
    • Pharmacology

    Cite this

    Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901. / Tanaka, Makoto; Miyazaki, Hiroyuki; Takeda, Yasuyuki; Takeo, Suguru; Yoshikai, Yasunobu; Nomoto, Kikuo.

    In: Immunopharmacology and Immunotoxicology, Vol. 14, No. 3, 01.01.1992, p. 403-420.

    Research output: Contribution to journalArticle

    Tanaka, Makoto ; Miyazaki, Hiroyuki ; Takeda, Yasuyuki ; Takeo, Suguru ; Yoshikai, Yasunobu ; Nomoto, Kikuo. / Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901. In: Immunopharmacology and Immunotoxicology. 1992 ; Vol. 14, No. 3. pp. 403-420.
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