Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901

Makoto Tanaka; Hiroyuki Miyazaki; Yasuyuki Takeda; Suguru Takeo; Yasunobu Yoshikai; Kikuo Nomoto

doi:10.3109/08923979209005401

Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901

Makoto Tanaka, Hiroyuki Miyazaki, Yasuyuki Takeda, Suguru Takeo, Yasunobu Yoshikai, Kikuo Nomoto

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.

Original language	English
Pages (from-to)	403-420
Number of pages	18
Journal	Immunopharmacology and Immunotoxicology
Volume	14
Issue number	3
DOIs	https://doi.org/10.3109/08923979209005401
Publication status	Published - Jan 1 1992

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Toxicology
Pharmacology

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Tanaka, M., Miyazaki, H., Takeda, Y., Takeo, S., Yoshikai, Y., & Nomoto, K. (1992). Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901. Immunopharmacology and Immunotoxicology, 14(3), 403-420. https://doi.org/10.3109/08923979209005401

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abstract = "The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an α1,3 branched α1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied. The augmentation effect on Con A-induced IL-2 production was evident when more than 30 mg/kg of SPR-901 was administered orally to mice. On the other hand, oral administration of B512 dextran, an analogous α1,6 glucan, did not show any augmentation effects on IL-2 production. The augmentation effect of SPR-901 on IL-2 production seemed to be mediated mainly by macrophages stimulated with SPR-901.",

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AU - Yoshikai, Yasunobu

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