Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells

Yojiro Arinobu, Rie Sugimoto, Mina Akaiwa, Kazuhiko Arima, Takeshi Otsuka, Naotaka Hamasaki, Kenji Izuhara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume277
Issue number2
DOIs
Publication statusPublished - Oct 22 2000

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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