Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (falfa) rats

Hiroaki Masuzaki, Kiminori Hosoda, Yoshihiro Ogawa, Michika Shigemoto, Noriko Satoh, Kiyoshi Mori, Naohisa Tamura, Shigeo Nishi, Yasunao Yoshimasa, Yukio Yamori, Kazuwa Nakao

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Abstract

Expression of the obese (ob) gene is up-regulated in the adipose tissue in several obese rodent models. To study the regulation of the ob gene expression during the development of obesity, we examined the ob gene expression in genetically obese-hyperglycemic Wistar fatty (falfa) rats at several stages of obesity. The ob mRNA levels in the adipose tissue from Wistar fatty rats was unequivocally augmented and continued to rise in the process of obesity. Furthermore, the ob gene expression in this obese model was much more rapidly enhanced in the mesenteric fat than in the subcutaneous fat. Moreover, the ob gene expression was more greatly augmented in the mesenteric fat than the lipoprotein lipase gene expression. These results suggest the presence of obesity-linked and region-specific regulation of the ob gene expression.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalFEBS Letters
Volume378
Issue number3
DOIs
Publication statusPublished - Jan 15 1996

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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    Masuzaki, H., Hosoda, K., Ogawa, Y., Shigemoto, M., Satoh, N., Mori, K., Tamura, N., Nishi, S., Yoshimasa, Y., Yamori, Y., & Nakao, K. (1996). Augmented expression of obese (ob) gene during the process of obesity in genetically obese-hyperglycemic Wistar fatty (falfa) rats. FEBS Letters, 378(3), 267-271. https://doi.org/10.1016/0014-5793(95)01472-1