Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation (Scientific Reports, (2017), 7, 1, (17762), 10.1038/s41598-017-17999-3)

Erika Castillo, Julio Leon, Guianfranco Mazzei, Nona Abolhassani, Naoki Haruyama, Takashi Saito, Takaomi Saido, Masaaki Hokama, Toru Iwaki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Kunihiko Sakumi, Frank M. LaFerla, Yusaku Nakabeppu

Research output: Contribution to journalComment/debatepeer-review

Abstract

This article contains errors in the Introduction, where “AppNL-G-F/NL-G-F mice carrying the homozygous mutant App gene encoding the humanised Aβ sequence (G601R, F606Y, and R609H) with three pathogenic mutations, namely Swedish (KM595/596NL), Beyreuther/Iberian (I641F), and Arctic (E618G)10, progressively exhibit Aβ accumulation starting at 4 to 6 months of age, dense distributions of microglia and astrocytes from 9 months of age, and behavioural symptoms from 8 to 12 months of age10,11.” should read: “AppNL-G-F/NL-G-F mice carrying the homozygous mutant App gene encoding the humanised Aβ sequence (G676R, F681Y, and R684H) with three pathogenic mutations, namely Swedish (KM670/671NL), Beyreuther/Iberian (I716F), and Arctic (E693G)10, progressively exhibit Aβ accumulation starting at 4 to 6 months of age, dense distributions of microglia and astrocytes from 9 months of age, and behavioural symptoms from 8 to 12 months of age10,11.” In addition, in the Methods section, under the subheading ‘Animals’, “Heterozygous App+/NL-G-F mice carrying humanised Aβ sequence (G601R, F606Y, R609H), Swedish (ML595/596NL), Beyreuther/Iberian (I641F), and Arctic (E618G) mutations, were previously established10.” should read: “Heterozygous App+/NL-G-F mice carrying humanised Aβ sequence (G676R, F681Y, R684H), Swedish (KM670/671NL), Beyreuther/Iberian (I716F), and Arctic (E693G) mutations, were previously established10.”

Original languageEnglish
Article number18377
JournalScientific reports
Volume11
Issue number1
DOIs
Publication statusPublished - Dec 2021

All Science Journal Classification (ASJC) codes

  • General

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