Autoimmune blistering disease with concurrent IgG antibodies to desmoglein 1 and BP180: Two cases

We report two cases with concurrent detection of antibodies to Desmoglein 1 and BP180. In Case 1, a 78-year-old man was diagnosed with bullous pemphigoid and had been treated with oral prednisolone for 2 years. He developed crusted erythema on his face and trunk despite the well-controlled state of his bullous pemphigoid. Direct immunofluorescence detected intracellular deposition of IgG in the epidermis, and anti-BP180 and anti-Dsg 1 antibodies were detected byenzy melinked immunosorbent assay. In Case 2, a 91-year-old woman had had pruritic erythema with crusting on her thighs, axillae, face, and back for 2 months. Treatment with topical steroids was ineffective, and edematous erythema and tense bullae developed on her lower limbs. Direct immunofluorescence detected linear deposition of IgG and C3 along the basement membrane zone. Anti-BP180 and anti-Dsg 1 antibodies were also detected by enzyme-linked immunosorbent assay.