Autoimmunity and autoimmune co-morbidities in psoriasis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takafumi Kadono, Takeshi Nakahara, Masutaka Furue

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor-α/interleukin-23/interleukin-17 axis is now known to be the major mechanism in the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is co-morbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune co-morbidities in psoriasis.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalImmunology
Volume154
Issue number1
DOIs
Publication statusPublished - May 2018

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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