Autoimmunity and autoimmune co-morbidities in psoriasis

Kazuhisa Furue, Takamichi Ito, Gaku Tsuji, Takafumi Kadono, Takeshi Nakahara, Masutaka Furue

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)

Abstract

Psoriasis is characterized by widespread scaly erythematous plaques that cause significant physical and psychological burdens for the affected individuals. Accelerated inflammation driven by the tumour necrosis factor-α/interleukin-23/interleukin-17 axis is now known to be the major mechanism in the development of psoriasis. In addition, psoriasis has an autoimmune nature that manifests as autoreactive T cells and is co-morbid with other autoimmune diseases, such as autoimmune bullous diseases, vitiligo, alopecia and thyroiditis. In this article, we review the recent topics on autoimmunity and autoimmune co-morbidities in psoriasis.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalImmunology
Volume154
Issue number1
DOIs
Publication statusPublished - May 2018

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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