Automated high-throughput and high-resolution cell deformability mapping system

S. Sakuma, F. Arai, M. Kaneko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We discuss the deformability of red blood cell (RBC) by using the developed system where it is composed of a vision sensor, a syringe pump and a microfluidic chip. The chip has a narrow channel for giving the mechanical restraint to the cell to be tested. The cell changes its shape while passing the narrow channel, and we can evaluate the cell deformability by monitoring the length of the cell in narrow channel. The cell deformability is evaluated by the cell extensibility where it is defined by the ratio between the cell length in narrow channel and the original diameter of the cell. The throughput of the constructed system is approximately 10 seconds/cell with an assistant of visual feedback control of the cell position.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages808-810
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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