Automated volumetric measurement of cerebrospinal fluid in sulci and lateral ventricles based on 3-D MR images

Hidetaka Arimura, T. Yoshiura, S. Kumazawa, H. Koga, S. Sakai, F. Mihara, H. Honda, F. Toyofuku, Y. Higashida

Research output: Contribution to journalConference article

2 Citations (Scopus)

Abstract

The purpose of this study was to develop an automated method for volumetric measurement of cerebrospinal fluid (CSF) in the sulci and lateral ventricles (LVs) based on three-dimensional (3-D) magnetic resonance (MR) images. The basic concept of our method is to extract the CSF spaces in the sulci and LVs separately in a brain by wrapping the brain tightly in a propagating surface determined with a level set method, which functions like as “plastic wrap.” The CSF spaces in the sulci and LVs were extracted by use of a logical XOR operation between the wrapped brain and the original segmented brain. We applied our method to high-resolution 3- D T1-weighted MR images of the whole brains obtained from 21 clinically diagnosed AD cases and 16 non-AD cases. As a result, CSF spaces in the sulci and LVs were extracted well separately. The mean volume ratios of CSF in LVs to a whole brain for AD patients and non-AD cases were 0.0496 and 0.0301, respectively, which indicated a significant difference (p < 0.01) by Student t test, and the ratios for sulci were 0.197 and 0.164, which also indicated a significant difference (p < 0.005). Our preliminary results showed that our method may be promising for measuring the CSF volumes.

Original languageEnglish
Pages (from-to)2300-2303
Number of pages4
JournalIFMBE Proceedings
Volume14
Issue number1
Publication statusPublished - Jan 1 2007
Event10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of
Duration: Aug 27 2006Sep 1 2006

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Cerebrospinal fluid
Magnetic resonance
Brain
Students
Plastics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomedical Engineering

Cite this

Arimura, H., Yoshiura, T., Kumazawa, S., Koga, H., Sakai, S., Mihara, F., ... Higashida, Y. (2007). Automated volumetric measurement of cerebrospinal fluid in sulci and lateral ventricles based on 3-D MR images. IFMBE Proceedings, 14(1), 2300-2303.

Automated volumetric measurement of cerebrospinal fluid in sulci and lateral ventricles based on 3-D MR images. / Arimura, Hidetaka; Yoshiura, T.; Kumazawa, S.; Koga, H.; Sakai, S.; Mihara, F.; Honda, H.; Toyofuku, F.; Higashida, Y.

In: IFMBE Proceedings, Vol. 14, No. 1, 01.01.2007, p. 2300-2303.

Research output: Contribution to journalConference article

Arimura, H, Yoshiura, T, Kumazawa, S, Koga, H, Sakai, S, Mihara, F, Honda, H, Toyofuku, F & Higashida, Y 2007, 'Automated volumetric measurement of cerebrospinal fluid in sulci and lateral ventricles based on 3-D MR images', IFMBE Proceedings, vol. 14, no. 1, pp. 2300-2303.
Arimura, Hidetaka ; Yoshiura, T. ; Kumazawa, S. ; Koga, H. ; Sakai, S. ; Mihara, F. ; Honda, H. ; Toyofuku, F. ; Higashida, Y. / Automated volumetric measurement of cerebrospinal fluid in sulci and lateral ventricles based on 3-D MR images. In: IFMBE Proceedings. 2007 ; Vol. 14, No. 1. pp. 2300-2303.
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