Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study

T. Taguchi, K. Ikeda, T. Shono, S. Goto, M. Kubota, T. Kawana, R. Hirose, T. Toyohara

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A typical case of megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is reported. The patient, an infant girl, was fed only by total intravenous nutrition and is now 3 years old. The distribution of several gut peptides was examined in the resected small intestine using an immunohistochemical method. Vasoactive intestinal polypeptide (VIP) and peptide histidine methionin (PHM)-containing nerve fibers were decreased; however, substance P- and leucine enkephalin (Leu-ENK)-containing fibers were increased. The imbalance between several kinds of gut peptides might be one of the causes of aperistalsis in MMIHS. This is the first report about the gut peptides of MMIHS.

Original languageEnglish
Pages (from-to)1264-1266
Number of pages3
JournalJournal of Pediatric Surgery
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 1989
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study'. Together they form a unique fingerprint.

  • Cite this