Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome: I. Immunohistochemical study

Tomoaki Taguchi, K. Ikeda, T. Shono, S. Goto, M. Kubota, T. Kawana, R. Hirose, T. Toyohara

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A typical case of megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is reported. The patient, an infant girl, was fed only by total intravenous nutrition and is now 3 years old. The distribution of several gut peptides was examined in the resected small intestine using an immunohistochemical method. Vasoactive intestinal polypeptide (VIP) and peptide histidine methionin (PHM)-containing nerve fibers were decreased; however, substance P- and leucine enkephalin (Leu-ENK)-containing fibers were increased. The imbalance between several kinds of gut peptides might be one of the causes of aperistalsis in MMIHS. This is the first report about the gut peptides of MMIHS.

Original languageEnglish
Pages (from-to)1264-1266
Number of pages3
JournalJournal of Pediatric Surgery
Volume24
Issue number12
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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Intestines
Vasoactive Intestinal Peptide
Peptides
Leucine Enkephalin
Substance P
Nerve Fibers
Histidine
Small Intestine
Megacystis microcolon intestinal hypoperistalsis syndrome

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome : I. Immunohistochemical study. / Taguchi, Tomoaki; Ikeda, K.; Shono, T.; Goto, S.; Kubota, M.; Kawana, T.; Hirose, R.; Toyohara, T.

In: Journal of Pediatric Surgery, Vol. 24, No. 12, 01.01.1989, p. 1264-1266.

Research output: Contribution to journalArticle

Taguchi, Tomoaki ; Ikeda, K. ; Shono, T. ; Goto, S. ; Kubota, M. ; Kawana, T. ; Hirose, R. ; Toyohara, T. / Autonomic innervation of the intestine from a baby with megacystis microcolon intestinal hypoperistalsis syndrome : I. Immunohistochemical study. In: Journal of Pediatric Surgery. 1989 ; Vol. 24, No. 12. pp. 1264-1266.
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