Autophagy in the fission yeast Schizosaccharomyces pombe

Hiroyuki Mukaiyama, Mai Nakase, Taro Nakamura, Yoshimi Kakinuma, Kaoru Takegawa

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Autophagy is a non-selective degradation process in eukaryotic cells. The genome sequence of the fission yeast Schizosaccharomyces pombe has revealed that many of the genes required for autophagy are common between the fission yeast and budding yeast, suggesting that the basic machinery of autophagy is conserved between these species. Autophagy in fission yeast is specifically induced by nitrogen starvation based on monitoring a GFP-Atg8p marker. Upon nitrogen starvation, fission yeast cells exit the vegetative cell cycle and initiate sexual differentiation to produce spores. Most of the nitrogen used for de novo protein synthesis during sporulation derives from the autophagic protein degradation system. This review focuses on the recent advances in the role of autophagy in fission yeast.

Original languageEnglish
Pages (from-to)1327-1334
Number of pages8
JournalFEBS Letters
Volume584
Issue number7
DOIs
Publication statusPublished - Apr 1 2010

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Schizosaccharomyces
Autophagy
Yeast
Nitrogen
Starvation
Genes
Cells
Degradation
Sex Differentiation
Saccharomycetales
Eukaryotic Cells
Spores
Proteolysis
Machinery
Cell Cycle
Proteins
Genome
Monitoring

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Autophagy in the fission yeast Schizosaccharomyces pombe. / Mukaiyama, Hiroyuki; Nakase, Mai; Nakamura, Taro; Kakinuma, Yoshimi; Takegawa, Kaoru.

In: FEBS Letters, Vol. 584, No. 7, 01.04.2010, p. 1327-1334.

Research output: Contribution to journalReview article

Mukaiyama, H, Nakase, M, Nakamura, T, Kakinuma, Y & Takegawa, K 2010, 'Autophagy in the fission yeast Schizosaccharomyces pombe', FEBS Letters, vol. 584, no. 7, pp. 1327-1334. https://doi.org/10.1016/j.febslet.2009.12.037
Mukaiyama, Hiroyuki ; Nakase, Mai ; Nakamura, Taro ; Kakinuma, Yoshimi ; Takegawa, Kaoru. / Autophagy in the fission yeast Schizosaccharomyces pombe. In: FEBS Letters. 2010 ; Vol. 584, No. 7. pp. 1327-1334.
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