Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication

Kana Unuma; Kazuki Harada; Makoto Nakajima; Hiromi Eguchi; Kensuke Tsushima; Takako Ito; Kaori Shintani-Ishida; Hideaki Kojima; Ken ichi Yoshida

doi:10.1016/j.forsciint.2009.09.003

Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication

Kana Unuma, Kazuki Harada, Makoto Nakajima, Hiromi Eguchi, Kensuke Tsushima, Takako Ito, Kaori Shintani-Ishida, Hideaki Kojima, Ken ichi Yoshida

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na⁺) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.

Original language	English
Pages (from-to)	e5-e8
Journal	Forensic Science International
Volume	194
Issue number	1-3
DOIs	https://doi.org/10.1016/j.forsciint.2009.09.003
Publication status	Published - Jan 30 2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine

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10.1016/j.forsciint.2009.09.003

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title = "Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication",

abstract = "An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na+) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.",

author = "Kana Unuma and Kazuki Harada and Makoto Nakajima and Hiromi Eguchi and Kensuke Tsushima and Takako Ito and Kaori Shintani-Ishida and Hideaki Kojima and Yoshida, {Ken ichi}",

note = "Funding Information: This paper is a part of a study supported by the Japan Society for the Promotion of Science (Grant No. 208791 ).",

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T1 - Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication

AU - Unuma, Kana

AU - Harada, Kazuki

AU - Nakajima, Makoto

AU - Eguchi, Hiromi

AU - Tsushima, Kensuke

AU - Ito, Takako

AU - Shintani-Ishida, Kaori

AU - Kojima, Hideaki

AU - Yoshida, Ken ichi

N1 - Funding Information: This paper is a part of a study supported by the Japan Society for the Promotion of Science (Grant No. 208791 ).

PY - 2010/1/30

Y1 - 2010/1/30

N2 - An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na+) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.

AB - An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na+) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.

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JO - Forensic Science International

JF - Forensic Science International

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IS - 1-3

ER -

Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication

Abstract

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