Abstract
We established a TCR Vβ6+ CD4+ autoreactive T cell line from lymph nodecells of unprimed BALB/c mice bred in a specific pathogen-free condition. The T cell line proliferated In the presenceof Irradiated spleen cells expressing MHC class II I-Ad and/or I-Ed molecules. The proliferatlveresponse of the autoreactive T cell line was significantly enhanced In response to 65 kd heat-shock protein (hsp) from Mycobacterium bovis, a member of the hsp60 family, which is highly conserved in both prokaryotes and eukaryotes. Our results suggest that the autoreactive T cells in normal mice may recognize endogenous peptldes of self-hsp60 bound to MHC class IIgene products and are cross-reactive to mycobacterial 65 kd hsp. The autoreactive hsp-specific T cells may therefore play an important role in the immune surveillance against invasion of various pathogens and tumors by recognizing Infected and transformed autoiogous cells that express high levels of endogenous hsp60.
| Original language | English |
|---|---|
| Pages (from-to) | 215-220 |
| Number of pages | 6 |
| Journal | International Immunology |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1 1991 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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Autoreactive T cells from normal mice recognize mycobacterial 65 kd heat-shock protein from mycobacterium bovis. / Matsuzaki, Goro; Yoshikal, Yasunobu; Harada, Mamoru; Nomoto, Kikuo.
In: International Immunology, Vol. 3, No. 2, 01.02.1991, p. 215-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoreactive T cells from normal mice recognize mycobacterial 65 kd heat-shock protein from mycobacterium bovis
AU - Matsuzaki, Goro
AU - Yoshikal, Yasunobu
AU - Harada, Mamoru
AU - Nomoto, Kikuo
PY - 1991/2/1
Y1 - 1991/2/1
N2 - We established a TCR Vβ6+ CD4+ autoreactive T cell line from lymph nodecells of unprimed BALB/c mice bred in a specific pathogen-free condition. The T cell line proliferated In the presenceof Irradiated spleen cells expressing MHC class II I-Ad and/or I-Ed molecules. The proliferatlveresponse of the autoreactive T cell line was significantly enhanced In response to 65 kd heat-shock protein (hsp) from Mycobacterium bovis, a member of the hsp60 family, which is highly conserved in both prokaryotes and eukaryotes. Our results suggest that the autoreactive T cells in normal mice may recognize endogenous peptldes of self-hsp60 bound to MHC class IIgene products and are cross-reactive to mycobacterial 65 kd hsp. The autoreactive hsp-specific T cells may therefore play an important role in the immune surveillance against invasion of various pathogens and tumors by recognizing Infected and transformed autoiogous cells that express high levels of endogenous hsp60.
AB - We established a TCR Vβ6+ CD4+ autoreactive T cell line from lymph nodecells of unprimed BALB/c mice bred in a specific pathogen-free condition. The T cell line proliferated In the presenceof Irradiated spleen cells expressing MHC class II I-Ad and/or I-Ed molecules. The proliferatlveresponse of the autoreactive T cell line was significantly enhanced In response to 65 kd heat-shock protein (hsp) from Mycobacterium bovis, a member of the hsp60 family, which is highly conserved in both prokaryotes and eukaryotes. Our results suggest that the autoreactive T cells in normal mice may recognize endogenous peptldes of self-hsp60 bound to MHC class IIgene products and are cross-reactive to mycobacterial 65 kd hsp. The autoreactive hsp-specific T cells may therefore play an important role in the immune surveillance against invasion of various pathogens and tumors by recognizing Infected and transformed autoiogous cells that express high levels of endogenous hsp60.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026028316&partnerID=8YFLogxK
U2 - 10.1093/intimm/3.2.215
DO - 10.1093/intimm/3.2.215
M3 - Article
C2 - 1709051
AN - SCOPUS:0026028316
VL - 3
SP - 215
EP - 220
JO - International Immunology
JF - International Immunology
SN - 0953-8178
IS - 2
ER -