Avian flu pandemic: Can we prevent it?

Shingo Iwami, Yasuhiro Takeuchi, Xianning Liu

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Outbreaks of highly pathogenic H5N1 avian influenza in Southeast Asia, Europe and Africa have led to devastating consequences for poultry, and have resulted in numerous infections in humans. Although these infections from the animal reservoir continue to accumulate, the virus does not seem to spread extensively among humans. However, for example, a process of genetic reassortment could occur in a human who is co-infected with avian influenza A virus and a human strain of influenza A virus. The resulting new virus might then be able to easily infect humans and spread from human to human. Therefore, many experts expect the occurrence of a pandemic due to a mutant virus which can be easily transmitted among humans. Thus, currently, a major public health concern is the next influenza pandemic; yet it remains unclear how to control such a crisis. In this paper, we investigate relations between the evolution of virulence and an effectiveness of pandemic control measures after the emergence of mutant avian influenza; one is an elimination policy of infected birds with avian influenza and the other is a quarantine policy of infected humans with mutant avian influenza. We found that each of these prevention policies can be ineffective (i.e., increase human morbidity or mortality). Further, interestingly, the same intervention might, under the same conditions, increase human morbidity and decrease human mortality, or vice versa. Our practical findings are that the quarantine policy can effectively reduce both human morbidity and mortality but the elimination policy increases either human morbidity or mortality in a worst case situation.

Original languageEnglish
Pages (from-to)181-190
Number of pages10
JournalJournal of Theoretical Biology
Volume257
Issue number1
DOIs
Publication statusPublished - Mar 7 2009
Externally publishedYes

Fingerprint

Influenza in Birds
avian influenza
Pandemics
pandemic
Viruses
Influenza
Morbidity
Virus
Mortality
morbidity
Poultry
Birds
Public health
Mutant
Quarantine
Influenza A virus
Animals
quarantine
Human
Human Influenza

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Avian flu pandemic : Can we prevent it? / Iwami, Shingo; Takeuchi, Yasuhiro; Liu, Xianning.

In: Journal of Theoretical Biology, Vol. 257, No. 1, 07.03.2009, p. 181-190.

Research output: Contribution to journalArticle

Iwami, Shingo ; Takeuchi, Yasuhiro ; Liu, Xianning. / Avian flu pandemic : Can we prevent it?. In: Journal of Theoretical Biology. 2009 ; Vol. 257, No. 1. pp. 181-190.
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