(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalOrganic Letters
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 23 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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