(-)-Axinyssene: A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp

Kota Kodama, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W.M. Van Soest

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

(Matrix presented) A novel diterpene, (-)-axinyssene, was isolated from the Japanese marine sponge Axinyssa sp. The structure of (-)-axinyssene was determined on the basis of spectroscopic and synthetic evidence to be 1-methyl-4-[(4E)-5′9′-dimethyl-1′-methylene-4′, 8′-decadienyl]-(4S)-cyclohexene. (-)- and (+)-axinyssene showed mild cytotoxicity against acute promyelocytic leukemia, HL-60 cells.

Original languageEnglish
Pages (from-to)169-171
Number of pages3
JournalOrganic Letters
Volume5
Issue number2
DOIs
Publication statusPublished - Jan 23 2003

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leukemias
Diterpenes
Military Personnel
Porifera
methylene
matrices
cells
Acute Promyelocytic Leukemia
HL-60 Cells
Cytotoxicity
axinyssene

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

(-)-Axinyssene : A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp. / Kodama, Kota; Higuchi, Ryuichi; Miyamoto, Tomofumi; Van Soest, Rob W.M.

In: Organic Letters, Vol. 5, No. 2, 23.01.2003, p. 169-171.

Research output: Contribution to journalArticle

Kodama, Kota ; Higuchi, Ryuichi ; Miyamoto, Tomofumi ; Van Soest, Rob W.M. / (-)-Axinyssene : A novel cytotoxic diterpene from a Japanese marine sponge Axinyssa sp. In: Organic Letters. 2003 ; Vol. 5, No. 2. pp. 169-171.
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