B lymphopoiesis in the thymus

Koichi Akashi, Lauren I. Richie, Toshihiro Miyamoto, William H. Carr, Irving L. Weissman

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

The thymus has been regarded as the major site of T cell differentiation. We find that in addition to αβ and γδ T cells, a significant number (~3 x 104 per day) of B220+IgM+ mature B cells are exported from the thymus of C57BL/6 mice. Of these emigrating B cells, we estimate that at least ~2 x 104 per day are cells which developed intrathymically, whereas a maximum of ~0.8 x 104 per day are cells which circulated through the thymus from the periphery. The thymus possesses a significant number of pro-B and pre-B cells that express CD19, VpreB, λ5, and pax-5. These B cell progenitors were found in the thymic cortex, whereas increasingly mature B cells were found in the corticomedullar and medullary regions. Other lymphoid cells, including NK cells and lymphoid dendritic cells, are not exported from the thymus at detectable levels. Thus, the thymus contributes to the formation of peripheral pools of B cells as well as of αβ and γδ T cells.

Original languageEnglish
Pages (from-to)5221-5226
Number of pages6
JournalJournal of Immunology
Volume164
Issue number10
DOIs
Publication statusPublished - May 15 2000
Externally publishedYes

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Lymphopoiesis
Thymus Gland
B-Lymphocytes
B-Lymphoid Precursor Cells
T-Lymphocytes
Lymphocytes
Inbred C57BL Mouse
Natural Killer Cells
Dendritic Cells
Immunoglobulin M
Cell Differentiation

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Akashi, K., Richie, L. I., Miyamoto, T., Carr, W. H., & Weissman, I. L. (2000). B lymphopoiesis in the thymus. Journal of Immunology, 164(10), 5221-5226. https://doi.org/10.4049/jimmunol.164.10.5221

B lymphopoiesis in the thymus. / Akashi, Koichi; Richie, Lauren I.; Miyamoto, Toshihiro; Carr, William H.; Weissman, Irving L.

In: Journal of Immunology, Vol. 164, No. 10, 15.05.2000, p. 5221-5226.

Research output: Contribution to journalArticle

Akashi, K, Richie, LI, Miyamoto, T, Carr, WH & Weissman, IL 2000, 'B lymphopoiesis in the thymus', Journal of Immunology, vol. 164, no. 10, pp. 5221-5226. https://doi.org/10.4049/jimmunol.164.10.5221
Akashi, Koichi ; Richie, Lauren I. ; Miyamoto, Toshihiro ; Carr, William H. ; Weissman, Irving L. / B lymphopoiesis in the thymus. In: Journal of Immunology. 2000 ; Vol. 164, No. 10. pp. 5221-5226.
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