B-Z transition of (dA-T)n duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation

Hideaki Sasaki; Shigeki Sasaki

doi:10.1039/c3cc45213a

B-Z transition of (dA-T)_n duplexes induced by a spermine porphyrin-conjugate via an intermediate DNA conformation

Hideaki Sasaki, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

The spermine conjugate of the cationic porphyrin ligand (1) selectively induced the B-Z transition of the [(dA-T)_n]₂ sequence at low salt concentrations. The [(dG-C)_n]₂ sequence was not transformed into the Z-form. The B-Z transition was induced via an intermediate DNA conformation, which was formed by the external binding and formation of an assembly of 1 onto B-DNA.

Original language	English
Pages (from-to)	9024-9026
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	79
DOIs	https://doi.org/10.1039/c3cc45213a
Publication status	Published - Sep 10 2013

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "The spermine conjugate of the cationic porphyrin ligand (1) selectively induced the B-Z transition of the [(dA-T)n]2 sequence at low salt concentrations. The [(dG-C)n]2 sequence was not transformed into the Z-form. The B-Z transition was induced via an intermediate DNA conformation, which was formed by the external binding and formation of an assembly of 1 onto B-DNA.",

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