B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

Koichiro Matsumoto, Satoru Fukuyama, Miyuki Eguchi-Tsuda, Takako Nakano, Takafumi Matsumoto, Mikiko Matsumura, Atsushi Moriwaki, Keiko Kan-o, Yoshihiro Wada, Hideo Yagita, Tahiro Shin, Drew M. Pardoll, Rirprajak Patcharee, Miyuki Azuma, Yoichi Nakanishi, Hiromasa Inoue

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume365
Issue number1
DOIs
Publication statusPublished - Jan 4 2008

Fingerprint

Interleukin-13
Asthma
Feedback
Dendritic Cells
Allergens
Phenotype
Molecules
Up-Regulation
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. / Matsumoto, Koichiro; Fukuyama, Satoru; Eguchi-Tsuda, Miyuki; Nakano, Takako; Matsumoto, Takafumi; Matsumura, Mikiko; Moriwaki, Atsushi; Kan-o, Keiko; Wada, Yoshihiro; Yagita, Hideo; Shin, Tahiro; Pardoll, Drew M.; Patcharee, Rirprajak; Azuma, Miyuki; Nakanishi, Yoichi; Inoue, Hiromasa.

In: Biochemical and Biophysical Research Communications, Vol. 365, No. 1, 04.01.2008, p. 170-175.

Research output: Contribution to journalArticle

Matsumoto, K, Fukuyama, S, Eguchi-Tsuda, M, Nakano, T, Matsumoto, T, Matsumura, M, Moriwaki, A, Kan-o, K, Wada, Y, Yagita, H, Shin, T, Pardoll, DM, Patcharee, R, Azuma, M, Nakanishi, Y & Inoue, H 2008, 'B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma', Biochemical and Biophysical Research Communications, vol. 365, no. 1, pp. 170-175. https://doi.org/10.1016/j.bbrc.2007.10.156
Matsumoto, Koichiro ; Fukuyama, Satoru ; Eguchi-Tsuda, Miyuki ; Nakano, Takako ; Matsumoto, Takafumi ; Matsumura, Mikiko ; Moriwaki, Atsushi ; Kan-o, Keiko ; Wada, Yoshihiro ; Yagita, Hideo ; Shin, Tahiro ; Pardoll, Drew M. ; Patcharee, Rirprajak ; Azuma, Miyuki ; Nakanishi, Yoichi ; Inoue, Hiromasa. / B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. In: Biochemical and Biophysical Research Communications. 2008 ; Vol. 365, No. 1. pp. 170-175.
@article{f2ba97f3e47546879bb08360dd3d5789,
title = "B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma",
abstract = "B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.",
author = "Koichiro Matsumoto and Satoru Fukuyama and Miyuki Eguchi-Tsuda and Takako Nakano and Takafumi Matsumoto and Mikiko Matsumura and Atsushi Moriwaki and Keiko Kan-o and Yoshihiro Wada and Hideo Yagita and Tahiro Shin and Pardoll, {Drew M.} and Rirprajak Patcharee and Miyuki Azuma and Yoichi Nakanishi and Hiromasa Inoue",
year = "2008",
month = "1",
day = "4",
doi = "10.1016/j.bbrc.2007.10.156",
language = "English",
volume = "365",
pages = "170--175",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma

AU - Matsumoto, Koichiro

AU - Fukuyama, Satoru

AU - Eguchi-Tsuda, Miyuki

AU - Nakano, Takako

AU - Matsumoto, Takafumi

AU - Matsumura, Mikiko

AU - Moriwaki, Atsushi

AU - Kan-o, Keiko

AU - Wada, Yoshihiro

AU - Yagita, Hideo

AU - Shin, Tahiro

AU - Pardoll, Drew M.

AU - Patcharee, Rirprajak

AU - Azuma, Miyuki

AU - Nakanishi, Yoichi

AU - Inoue, Hiromasa

PY - 2008/1/4

Y1 - 2008/1/4

N2 - B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

AB - B7-DC is a costimulatory molecule belonging to the B7 family. We previously found that treatment with anti-B7-DC mAb during the effector phase enhances asthma phenotypes in mice. We investigated the mechanisms of B7-DC induction and how B7-DC regulates asthma phenotypes. In allergen-challenged IFN-γ-deficient mice, anti-B7-DC mAb failed to enhance the asthma phenotypes although the induction of B7-DC on dendritic cells of the mice was comparable with that on dendritic cells of wild-type mice. B7-DC on dendritic cells was up-regulated by IL-13 in vitro. The induction of B7-DC on dendritic cells after allergen challenge was attenuated by blockade of IL-13 in vivo. The asthma phenotypes were enhanced in B7-DC-deficient mice, more than in wild-type mice. The enhancement was concurrent with the down-regulation of IFN-γ and up-regulation of IL-13. These results suggest that B7-DC induced by IL-13 works as a feedback regulator by up-regulating IFN-γ production during the effector phase of allergic asthma.

UR - http://www.scopus.com/inward/record.url?scp=36049010929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36049010929&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2007.10.156

DO - 10.1016/j.bbrc.2007.10.156

M3 - Article

C2 - 17981145

AN - SCOPUS:36049010929

VL - 365

SP - 170

EP - 175

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -