Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation

Yoshihiko Soga, Yoshinobu Maeda, Fumihiko Ishimaru, Mitsune Tanimoto, Hiroshi Maeda, Fusanori Nishimura, Shogo Takashiba

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Methods Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. Results The changes in detection frequencies of CoNS and α-streptococci from before to 3 weeks after HCT were significant (P<0.05, χ2 test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P<0.05, χ2 test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Conclusion Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.

Original languageEnglish
Pages (from-to)995-1000
Number of pages6
JournalSupportive Care in Cancer
Volume19
Issue number7
DOIs
Publication statusPublished - Jul 1 2011

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Coagulase
Cell Transplantation
Mouth Mucosa
Streptococcus
Staphylococcus
Anti-Bacterial Agents
Stomatitis
Infection
Bacteria
Central Venous Catheters

All Science Journal Classification (ASJC) codes

  • Oncology

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Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation. / Soga, Yoshihiko; Maeda, Yoshinobu; Ishimaru, Fumihiko; Tanimoto, Mitsune; Maeda, Hiroshi; Nishimura, Fusanori; Takashiba, Shogo.

In: Supportive Care in Cancer, Vol. 19, No. 7, 01.07.2011, p. 995-1000.

Research output: Contribution to journalArticle

Soga, Yoshihiko ; Maeda, Yoshinobu ; Ishimaru, Fumihiko ; Tanimoto, Mitsune ; Maeda, Hiroshi ; Nishimura, Fusanori ; Takashiba, Shogo. / Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation. In: Supportive Care in Cancer. 2011 ; Vol. 19, No. 7. pp. 995-1000.
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abstract = "Purpose Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Methods Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. Results The changes in detection frequencies of CoNS and α-streptococci from before to 3 weeks after HCT were significant (P<0.05, χ2 test): 14.5-53.3{\%} and 92.7-53.1{\%}, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P<0.05, χ2 test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Conclusion Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.",
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N2 - Purpose Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Methods Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. Results The changes in detection frequencies of CoNS and α-streptococci from before to 3 weeks after HCT were significant (P<0.05, χ2 test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P<0.05, χ2 test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Conclusion Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.

AB - Purpose Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients. Generally, the use of central venous catheters is recognized as a significant risk factor for CoNS infection, while the impact of CoNS infection from oral ulcerative mucositis, which occurs frequently in HCT, may be underestimated. Here, we examined the bacteria on the buccal mucosa after HCT. Methods Sixty-one patients were examined for bacteria on the buccal mucosa routinely once a week from 1 week before to 3 weeks after allogeneic HCT. Subjects were divided into groups with short and long periods of antibiotic use, and differences in bacterial substitution were evaluated. The relationships between type of HCT (conventional HCT or RIST) and bacterial substitution were also evaluated. Results The changes in detection frequencies of CoNS and α-streptococci from before to 3 weeks after HCT were significant (P<0.05, χ2 test): 14.5-53.3% and 92.7-53.1%, respectively. Significant bacterial substitution of CoNS for streptococci was observed in the long-term antibiotic use group (P<0.05, χ2 test), but also occurred in cases with short-term or no antibiotic use. No relationships between type of HCT (conventional HCT or RIST) were observed. Conclusion Bacterial substitution of CoNS for streptococci occurred frequently on the buccal mucosa after HCT. In addition to antibiotic use, environmental factors may be involved in bacterial substitution. It is important to consider the presence of oral mucositis in CoNS infection after HCT.

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