Baroreflex sensitivity might predict responders to milrinone in patients with heart failure

Takuya Kishi, Kenji Sunagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The phosphodiesterase III inhibitor milrinone (MIL) is considered to be effective for "wet and cold" heart failure. In some cases, however, the inotropic effects of milrinone are insuffcient. A previous study suggested that barorefex sensitivity (BRS) predicts the cases in which MIL increases left ventricular dp/dt. The aim of this study was to determine whether BRS measured using the spontaneous sequence method predicts the MIL responders. Twenty-four patients with "wet and cold" heart failure whose systolic blood pressure > 100 mmHg were enrolled. At 2 hours MIL improved dyspnea, general fatigue, urine volume, and tricuspid regurgitant pressure gradient in 13 patients (responders; R group), whereas it failed to improve in 11 patients (nonresponders; NR group). BRS in the R group was significantly higher than that in the NR group prior to the MIL infusion. At 2 hours after the MIL infusion, BRS was further increased in the R group, but did not increase in the NR group. The sensitivity and specificity of BRS at a cut-off level of 5 ms/mmHg for the prediction of R group were 0.94 and 0.93, respectively. BRS might be useful for identifying potential responders to milrinone in patients with blood pressure-preserved "wet and cold" heart failure.

Original languageEnglish
Pages (from-to)411-415
Number of pages5
JournalInternational heart journal
Volume51
Issue number6
DOIs
Publication statusPublished - Dec 31 2010

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Milrinone
Baroreflex
Heart Failure
Blood Pressure
Type 3 Cyclic Nucleotide Phosphodiesterases
Phosphodiesterase Inhibitors
Dyspnea
Fatigue
Urine
Pressure
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Baroreflex sensitivity might predict responders to milrinone in patients with heart failure. / Kishi, Takuya; Sunagawa, Kenji.

In: International heart journal, Vol. 51, No. 6, 31.12.2010, p. 411-415.

Research output: Contribution to journalArticle

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