Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation

Hiromitsu Araki, Fumihito Miura, Akira Watanabe, Chikako Morinaga, Fumiyo Kitaoka, Yuko Kitano, Noriko Sakai, Yumiko Shibata, Motoki Terada, So Goto, Shinya Yamanaka, Masayo Takahashi, Takashi Ito

Research output: Contribution to journalArticle

Abstract

In this article, Ito and colleagues delineated the base-resolution methylome of iPSC-derived retinal pigment epithelial (RPE) cell used in the first-in-human trial of autologous transplantation. The methylome closely resembled that of native RPE cell. Intriguingly, it became even closer to its natural counterpart upon xenotransplantation to mouse, demonstrating its plasticity to respond appropriately to the in vivo environment.

Original languageEnglish
Pages (from-to)761-774
Number of pages14
JournalStem Cell Reports
Volume13
Issue number4
DOIs
Publication statusPublished - Oct 8 2019

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Induced Pluripotent Stem Cells
Retinal Pigments
Autologous Transplantation
Stem cells
Epithelial Cells
Heterologous Transplantation
Plasticity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Developmental Biology
  • Cell Biology

Cite this

Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. / Araki, Hiromitsu; Miura, Fumihito; Watanabe, Akira; Morinaga, Chikako; Kitaoka, Fumiyo; Kitano, Yuko; Sakai, Noriko; Shibata, Yumiko; Terada, Motoki; Goto, So; Yamanaka, Shinya; Takahashi, Masayo; Ito, Takashi.

In: Stem Cell Reports, Vol. 13, No. 4, 08.10.2019, p. 761-774.

Research output: Contribution to journalArticle

Araki, Hiromitsu ; Miura, Fumihito ; Watanabe, Akira ; Morinaga, Chikako ; Kitaoka, Fumiyo ; Kitano, Yuko ; Sakai, Noriko ; Shibata, Yumiko ; Terada, Motoki ; Goto, So ; Yamanaka, Shinya ; Takahashi, Masayo ; Ito, Takashi. / Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation. In: Stem Cell Reports. 2019 ; Vol. 13, No. 4. pp. 761-774.
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