Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report

AMD2000 Study Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To report research participants’ baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging. Methods: Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography. Results: Four hundred sixty participants (326 men [70.9%]) were included in the study. At enrollment, 131 eyes (28.5%) had hard drusen and 125 eyes (27.2%) had soft drusen in the macular area. A total of 455 eyes (98.9%) were diagnosed as having wet AMD, and 5 eyes (1.1%), as having dry AMD. Of the 455 eyes with wet AMD, 209 eyes (45.4%) had typical AMD, 228 eyes (49.6%) had polypoidal choroidal vasculopathy (PCV), and 18 eyes (3.9%) had retinal angiomatous proliferation. The size of choroidal neovascularization (CNV) was significantly smaller with indocyanine green angiography than with fluorescein angiography (P OpenSPiltSPi 0.001). Poor baseline visual acuity was associated with cystoid macular edema, older age, scar, extrafoveal macular edema, subfoveal CNV, large branching vascular network, and hard exudates. Conclusion: Japanese patients with AMD are predominantly male, lack drusen, and have a high rate of PCV.

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalJapanese Journal of Ophthalmology
Volume62
Issue number2
DOIs
Publication statusPublished - Mar 1 2018

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Macular Degeneration
Cohort Studies
Prospective Studies
Choroidal Neovascularization
Indocyanine Green
Macular Edema
Visual Acuity
Angiography
Multimodal Imaging
Ophthalmoscopy
Fluorescein Angiography
Photography
Contact Lenses
Optical Coherence Tomography
Exudates and Transudates
Fluorescein
Cicatrix
Observational Studies
Blood Vessels
Japan

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration : an AMD2000 report. / AMD2000 Study Group.

In: Japanese Journal of Ophthalmology, Vol. 62, No. 2, 01.03.2018, p. 127-136.

Research output: Contribution to journalArticle

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title = "Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report",
abstract = "Purpose: To report research participants’ baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging. Methods: Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography. Results: Four hundred sixty participants (326 men [70.9{\%}]) were included in the study. At enrollment, 131 eyes (28.5{\%}) had hard drusen and 125 eyes (27.2{\%}) had soft drusen in the macular area. A total of 455 eyes (98.9{\%}) were diagnosed as having wet AMD, and 5 eyes (1.1{\%}), as having dry AMD. Of the 455 eyes with wet AMD, 209 eyes (45.4{\%}) had typical AMD, 228 eyes (49.6{\%}) had polypoidal choroidal vasculopathy (PCV), and 18 eyes (3.9{\%}) had retinal angiomatous proliferation. The size of choroidal neovascularization (CNV) was significantly smaller with indocyanine green angiography than with fluorescein angiography (P OpenSPiltSPi 0.001). Poor baseline visual acuity was associated with cystoid macular edema, older age, scar, extrafoveal macular edema, subfoveal CNV, large branching vascular network, and hard exudates. Conclusion: Japanese patients with AMD are predominantly male, lack drusen, and have a high rate of PCV.",
author = "{AMD2000 Study Group} and Akitaka Tsujikawa and Yumiko Akagi-Kurashige and Mitsuko Yuzawa and Tatsuro Ishibashi and Hideo Nakanishi and Eiji Nakatani and Satoshi Teramukai and Masanori Fukushima and Nagahisa Yoshimura",
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T1 - Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration

T2 - an AMD2000 report

AU - AMD2000 Study Group

AU - Tsujikawa, Akitaka

AU - Akagi-Kurashige, Yumiko

AU - Yuzawa, Mitsuko

AU - Ishibashi, Tatsuro

AU - Nakanishi, Hideo

AU - Nakatani, Eiji

AU - Teramukai, Satoshi

AU - Fukushima, Masanori

AU - Yoshimura, Nagahisa

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: To report research participants’ baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging. Methods: Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography. Results: Four hundred sixty participants (326 men [70.9%]) were included in the study. At enrollment, 131 eyes (28.5%) had hard drusen and 125 eyes (27.2%) had soft drusen in the macular area. A total of 455 eyes (98.9%) were diagnosed as having wet AMD, and 5 eyes (1.1%), as having dry AMD. Of the 455 eyes with wet AMD, 209 eyes (45.4%) had typical AMD, 228 eyes (49.6%) had polypoidal choroidal vasculopathy (PCV), and 18 eyes (3.9%) had retinal angiomatous proliferation. The size of choroidal neovascularization (CNV) was significantly smaller with indocyanine green angiography than with fluorescein angiography (P OpenSPiltSPi 0.001). Poor baseline visual acuity was associated with cystoid macular edema, older age, scar, extrafoveal macular edema, subfoveal CNV, large branching vascular network, and hard exudates. Conclusion: Japanese patients with AMD are predominantly male, lack drusen, and have a high rate of PCV.

AB - Purpose: To report research participants’ baseline characteristics in the AMD2000 study, a prospective, multicenter, 5-year, observational cohort study of Japanese age-related macular degeneration (AMD). The characteristics were determined using multimodal imaging. Methods: Patients with AMD were recruited at 18 clinical sites in Japan between April 2006 and March 2009. Each patient underwent a complete ophthalmic examination, including measurement of best-corrected visual acuity (Landolt chart), indirect ophthalmoscopy, slit-lamp biomicroscopy with a contact lens, optical coherence tomography imaging, fundus photography, and fluorescein and indocyanine green angiography. Results: Four hundred sixty participants (326 men [70.9%]) were included in the study. At enrollment, 131 eyes (28.5%) had hard drusen and 125 eyes (27.2%) had soft drusen in the macular area. A total of 455 eyes (98.9%) were diagnosed as having wet AMD, and 5 eyes (1.1%), as having dry AMD. Of the 455 eyes with wet AMD, 209 eyes (45.4%) had typical AMD, 228 eyes (49.6%) had polypoidal choroidal vasculopathy (PCV), and 18 eyes (3.9%) had retinal angiomatous proliferation. The size of choroidal neovascularization (CNV) was significantly smaller with indocyanine green angiography than with fluorescein angiography (P OpenSPiltSPi 0.001). Poor baseline visual acuity was associated with cystoid macular edema, older age, scar, extrafoveal macular edema, subfoveal CNV, large branching vascular network, and hard exudates. Conclusion: Japanese patients with AMD are predominantly male, lack drusen, and have a high rate of PCV.

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