Bassiamide A, a new alkaloid from xero-halophyte Bassia indica Wight.

Ahmed Othman, Yhiya Amen, Masako Matsumoto, Maki Nagata, Kuniyoshi Shimizu

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5 Citations (Scopus)


N-[(3-(3-methyl-1-oxo-butyl)amino)propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide (7), named ‘Bassiamide A’, a new alkaloid, together with six known compounds including one lignan (1) and five lignanamides (2–6), were isolated from the aerial parts of Bassia indica Wight. The study also reported an optimal separation of a rare occurring R-isomer lignanamide derivative (6) from a natural origin, in addition to its known corresponding S-isomer (5). Structures of isolated compounds were elucidated based on NMR spectroscopic data, HR-MS, and comparison with known related ones, and they were identified as syringaresinol (1), N-trans-feruloyl-3-methoxytyramine (2), N-trans-feruloyltyramine (3), S-(-)-N-trans-feruloyl normetanephrine (4), S-(-)-N-trans-feruloyl octopamine (5), R-(+)-N-trans-feruloyl octopamine (6). The isolated compounds were evaluated for their anti-acetylcholinesterase activity, and they showed weak inhibitory activity.

Original languageEnglish
JournalNatural Product Research
Publication statusAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry


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