TY - JOUR
T1 - Ba2+ current oscillation evoked by bradykinin in ras-transformed fibroblasts
AU - Higashida, Haruhiro
AU - Hoshi, Naoto
AU - Hashii, Minako
AU - Fu, Tao
AU - Noda, Mami
AU - Nozawa, Yoshinori
N1 - Funding Information:
We thank Dr. Y. Sugimoto for cells and Dr. J. E. Merritt for SK&F 96365. This investigation was supported in part by research grants from the Ministry of Education, Science and Culture of Japan.
PY - 1991/7/31
Y1 - 1991/7/31
N2 - By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH 3T3 cells. The current oscillation was infrequently observed in control NIH 3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH 3T3 cells.
AB - By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH 3T3 cells. The current oscillation was infrequently observed in control NIH 3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH 3T3 cells.
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U2 - 10.1016/0006-291X(91)90166-5
DO - 10.1016/0006-291X(91)90166-5
M3 - Article
C2 - 1859426
AN - SCOPUS:0026360218
SN - 0006-291X
VL - 178
SP - 713
EP - 717
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -