Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique

K. Ninomiya, Hidetaka Arimura, M. Sasahara, T. Hirose, Ohga Saiji, Y. Umezu, Hiroshi Honda, Tomonari Sasaki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Our aim was to develop a Bayesian delineation framework of clinical target volumes (CTVs) for prostate cancer radiotherapy using an anatomical-features-based machine learning (AF-ML) technique. Probabilistic atlases (PAs) of the pelvic bone and the CTV were generated from 43 training cases. Translation vectors, which could move the CTV PAs to CTV locations, were estimated using the AF-ML after a bone-based registration between the PAs and planning computed tomography (CT) images. An input vector derived from 11 AF points was fed to three AF-ML techniques (artificial neural network: ANN, random forest: RF, support vector machine: SVM). The AF points were selected from edge points and centroids of anatomical structures around prostate. Reference translation vectors between centroids of CTV PAs and CTVs were given to the AF-ML as teaching data. The CTV regions were extracted by thresholding posterior probabilities produced by using the Bayesian inference with the translated CTV PA and likelihoods of planning CT values. The framework was evaluated based on a leave-one-out test with CTV contours determined by radiation oncologists. Average location errors of CTV PAs along the anterior-posterior and superior-inferior directions without AF-ML were 5.7±4.6 mm and 5.5±4.3 mm, respectively, whereas the errors along the two directions with ANN, which showed the best performance, were 2.4±1.7 mm and 2.2±2.2 mm, respectively. The average Dice's similarity coefficient between reference and estimated CTVs for 44 test cases were 0.81±0.062 with ANN. The framework using AF-ML could accurately estimate CTVs of prostate cancer radiotherapy.

Original languageEnglish
Title of host publicationMedical Imaging 2018
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Robert J. Webster
PublisherSPIE
ISBN (Electronic)9781510616417
DOIs
Publication statusPublished - Jan 1 2018
EventMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling - Houston, United States
Duration: Feb 12 2018Feb 15 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10576
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling
CountryUnited States
CityHouston
Period2/12/182/15/18

Fingerprint

machine learning
delineation
Atlases
Radiotherapy
Learning systems
radiation therapy
Prostatic Neoplasms
cancer
Tomography
Bone
Pelvic Bones
Planning
centroids
bones
Support vector machines
planning
Machine Learning
Prostate
Teaching
education

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Ninomiya, K., Arimura, H., Sasahara, M., Hirose, T., Saiji, O., Umezu, Y., ... Sasaki, T. (2018). Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique. In B. Fei, & R. J. Webster (Eds.), Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling [105761Z] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10576). SPIE. https://doi.org/10.1117/12.2293463

Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique. / Ninomiya, K.; Arimura, Hidetaka; Sasahara, M.; Hirose, T.; Saiji, Ohga; Umezu, Y.; Honda, Hiroshi; Sasaki, Tomonari.

Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling. ed. / Baowei Fei; Robert J. Webster. SPIE, 2018. 105761Z (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10576).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ninomiya, K, Arimura, H, Sasahara, M, Hirose, T, Saiji, O, Umezu, Y, Honda, H & Sasaki, T 2018, Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique. in B Fei & RJ Webster (eds), Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling., 105761Z, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10576, SPIE, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling, Houston, United States, 2/12/18. https://doi.org/10.1117/12.2293463
Ninomiya K, Arimura H, Sasahara M, Hirose T, Saiji O, Umezu Y et al. Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique. In Fei B, Webster RJ, editors, Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling. SPIE. 2018. 105761Z. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2293463
Ninomiya, K. ; Arimura, Hidetaka ; Sasahara, M. ; Hirose, T. ; Saiji, Ohga ; Umezu, Y. ; Honda, Hiroshi ; Sasaki, Tomonari. / Bayesian delineation framework of clinical target volumes for prostate cancer radiotherapy using an anatomical-features-based machine learning technique. Medical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling. editor / Baowei Fei ; Robert J. Webster. SPIE, 2018. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).
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