Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice

Motonari Kondo, Koichi Akashi, Jos Domen, Kazuo Sugamura, Irving L. Weissman

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

The common cytokine receptor γ chain (γ{c) is an indispensable subunit for the formation of lymphoid-related cytokine receptors, including IL-7 and IL-15 receptors, that mediate nonredundant or critical signals for the differentiation of T and B cells and natural killer (NK) cells, respectively. We introduced the bcl-2 transgene driven by Eμ or H-2K promoters into γ(c)-deficient mice that lack all three lymphoid subclasses. The forced expression of Bcl-2 restored all stages of T lymphopoiesis, but not B or NK cell development, indicating that a primary function of γ(c)- mediated signals in the T lineage might be to maintain cell survival. Therefore, the development of T, B, and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated by coupling of γ(c)-related receptors.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalImmunity
Volume7
Issue number1
DOIs
Publication statusPublished - Jul 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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