Bcl6 mediates the development of T follicular helper cells

Roza I. Nurieva, Yeonseok Chung, Gustavo J. Martinez, Xuexian O. Yang, Shinya Tanaka, Tatyana D. Matskevitch, Yi Hong Wang, Chen Dong

Research output: Contribution to journalArticle

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Abstract

A fundamental function of CD4+ helper (TH) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (TFH) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in TFH cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced TFH-related gene expression and inhibited other TH lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired TFH cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of TFH cell generation.

Original languageEnglish
Pages (from-to)1001-1005
Number of pages5
JournalScience
Volume325
Issue number5943
DOIs
Publication statusPublished - Aug 31 2009
Externally publishedYes

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Helper-Inducer T-Lymphocytes
Interleukin-6
B-Lymphocytes
Th17 Cells
Germinal Center
T-Lymphocyte Subsets
Cell Lineage
Humoral Immunity
Cellular Immunity
Cell Differentiation
Transcription Factors
Cytokines
T-Lymphocytes
Gene Expression
DNA
interleukin-21

All Science Journal Classification (ASJC) codes

  • General

Cite this

Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., ... Dong, C. (2009). Bcl6 mediates the development of T follicular helper cells. Science, 325(5943), 1001-1005. https://doi.org/10.1126/science.1176676

Bcl6 mediates the development of T follicular helper cells. / Nurieva, Roza I.; Chung, Yeonseok; Martinez, Gustavo J.; Yang, Xuexian O.; Tanaka, Shinya; Matskevitch, Tatyana D.; Wang, Yi Hong; Dong, Chen.

In: Science, Vol. 325, No. 5943, 31.08.2009, p. 1001-1005.

Research output: Contribution to journalArticle

Nurieva, RI, Chung, Y, Martinez, GJ, Yang, XO, Tanaka, S, Matskevitch, TD, Wang, YH & Dong, C 2009, 'Bcl6 mediates the development of T follicular helper cells', Science, vol. 325, no. 5943, pp. 1001-1005. https://doi.org/10.1126/science.1176676
Nurieva RI, Chung Y, Martinez GJ, Yang XO, Tanaka S, Matskevitch TD et al. Bcl6 mediates the development of T follicular helper cells. Science. 2009 Aug 31;325(5943):1001-1005. https://doi.org/10.1126/science.1176676
Nurieva, Roza I. ; Chung, Yeonseok ; Martinez, Gustavo J. ; Yang, Xuexian O. ; Tanaka, Shinya ; Matskevitch, Tatyana D. ; Wang, Yi Hong ; Dong, Chen. / Bcl6 mediates the development of T follicular helper cells. In: Science. 2009 ; Vol. 325, No. 5943. pp. 1001-1005.
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