Behçet's disease associated with complement component 9 (C9) deficiency

Takahiko Horiuchi, H. Tsukamoto, T. Sawabe, S. Harashima, C. Morita, Y. Kashiwagi, D. Himeji, K. Masumoto, T. Otsuka, T. Kusaba, K. Nagasawa

Research output: Contribution to journalArticle

Abstract

Behçet's disease is a multisystem inflammatory disorder with unknown etiology. It has been shown that the titer of plasma complement component 9 (C9) is a good indicator of the disease activity. Therefore, the involvement of C9 in the pathogenesis of Behçet's disease has been suggested. We report a case of Behçet's disease associated with complete C9 deficiency (C9D) carrying the homozygous nonsense mutation at Arg-95 of C9 (R95X). The patient presented the typical characteristics of Behçet's disease, such as uveitis, recurrent oral aphthae and genital ulcers, and arthritis, suggesting that C9 does not play an essential role in the pathogenesis of Behçet's disease.

Original languageEnglish
Pages (from-to)276-278
Number of pages3
JournalModern Rheumatology
Volume10
Issue number4
DOIs
Publication statusPublished - Jan 12 2000

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Complement C9
Aphthous Stomatitis
Nonsense Codon
Uveitis
Ulcer
Arthritis
C9 Deficiency

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Horiuchi, T., Tsukamoto, H., Sawabe, T., Harashima, S., Morita, C., Kashiwagi, Y., ... Nagasawa, K. (2000). Behçet's disease associated with complement component 9 (C9) deficiency. Modern Rheumatology, 10(4), 276-278. https://doi.org/10.3109/s101650070017

Behçet's disease associated with complement component 9 (C9) deficiency. / Horiuchi, Takahiko; Tsukamoto, H.; Sawabe, T.; Harashima, S.; Morita, C.; Kashiwagi, Y.; Himeji, D.; Masumoto, K.; Otsuka, T.; Kusaba, T.; Nagasawa, K.

In: Modern Rheumatology, Vol. 10, No. 4, 12.01.2000, p. 276-278.

Research output: Contribution to journalArticle

Horiuchi, T, Tsukamoto, H, Sawabe, T, Harashima, S, Morita, C, Kashiwagi, Y, Himeji, D, Masumoto, K, Otsuka, T, Kusaba, T & Nagasawa, K 2000, 'Behçet's disease associated with complement component 9 (C9) deficiency', Modern Rheumatology, vol. 10, no. 4, pp. 276-278. https://doi.org/10.3109/s101650070017
Horiuchi T, Tsukamoto H, Sawabe T, Harashima S, Morita C, Kashiwagi Y et al. Behçet's disease associated with complement component 9 (C9) deficiency. Modern Rheumatology. 2000 Jan 12;10(4):276-278. https://doi.org/10.3109/s101650070017
Horiuchi, Takahiko ; Tsukamoto, H. ; Sawabe, T. ; Harashima, S. ; Morita, C. ; Kashiwagi, Y. ; Himeji, D. ; Masumoto, K. ; Otsuka, T. ; Kusaba, T. ; Nagasawa, K. / Behçet's disease associated with complement component 9 (C9) deficiency. In: Modern Rheumatology. 2000 ; Vol. 10, No. 4. pp. 276-278.
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