Behçet's disease ocular attack score 24: Evaluation of ocular disease activity before and after initiation of infliximab

Toshikatsu Kaburaki, Kenichi Namba, Koh Hei Sonoda, Takeshi Kezuka, Hiroshi Keino, Takako Fukuhara, Koju Kamoi, Kei Nakai, Nobuhisa Mizuki, Nobuyuki Ohguro

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Purpose: We developed a novel scoring system for uveitis due to Behçet's disease (BD), termed Behçet's disease ocular attack score 24 (BOS24), and examined its validity and usefulness by estimating changes in ocular disease activities both before and after initiation of infliximab therapy. Methods: BOS24 consists of a total 24 points divided into 6 parameters of ocular inflammatory symptoms. To examine the validity of our scoring system, 5 uveitis specialists examined the severity of 50 ocular attacks in clinical charts using both our system and a physician's impression score (grade 1-10). In addition, ocular disease activities both before and after initiation of infliximab were retrospectively examined in 150 cases of ocular BD using BOS24. Results: The average BOS24 for the 5 doctors was highly correlated with the average physician's impression score (p < 0.0001), whereas the coefficient of variance for BOS24 among doctors was much lower than that for the physician's impression score (p < 0.0001). Summation of BOS24 over a 6-month period (BOS24-6M) was significantly reduced after starting infliximab therapy (p < 0.0001). The average BOS24 for individual ocular attacks was also significantly decreased after starting infliximab, with scores for the posterior pole and fovea notably improved. Conclusions: BOS24 was highly related to severity noted by the physician's impression and had a low level of variability among the examined doctors. Using our novel scoring system, infliximab therapy was shown to reduce not only the frequency of ocular attacks, but also the severity of each attack. BOS24 is a promising tool for evaluating ocular BD activities.

Original languageEnglish
Pages (from-to)120-130
Number of pages11
JournalJapanese Journal of Ophthalmology
Volume58
Issue number2
DOIs
Publication statusPublished - Mar 2014

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Fingerprint Dive into the research topics of 'Behçet's disease ocular attack score 24: Evaluation of ocular disease activity before and after initiation of infliximab'. Together they form a unique fingerprint.

  • Cite this