TY - JOUR
T1 - Behavioural response of cells and bacteria on single and multiple doped Sr and Ag S53P4 sol-gel bioglass
AU - Swe, Thet Thet
AU - Shariff, Khairul Anuar
AU - Mohamad, Hasmaliza
AU - Ishikawa, Kunio
AU - Hayashi, Koichiro
AU - Abu Bakar, Mohamad Hafizi
N1 - Funding Information:
The authors would like to thank AUN/SEED-Net (Grant no: 6050368/A119 ), Fundamental Research Grant Scheme (FRGS-Grant no: 6071423 ), Ministry of Education Malaysia and Universiti Sains Malaysia (Short Term Research Grant, Grant no: 304/PBAHAN/60313046 ) for their financial support and assistance.
Publisher Copyright:
© 2020 Elsevier Ltd and Techna Group S.r.l.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - The aim of this study is to investigate the response of cells and bacteria on Sr, Ag, and Sr + Ag doped S53P4 sol-gel bioglass. In this study, 3 mol% of SrO and 1 mol% of Ag2O were selected as doping for single and multiple doped S53P4 sol-gel bioglass. These doped specimens were denoted as BG, BG-3S, BG-1A, and BG-3S1A throughout the study. Cell study showed that the BG-3S1A specimen exhibited the highest proliferation of MC3T3-E1 osteoblast-like cells, ALP activity, and bone nodule formation in comparison with other specimens. Meanwhile, antibacterial study of the BG-3S1A specimen showed relatively similar antibacterial responses towards Escherichia coli and Staphylococcus aureus in comparison with the BG-1A specimen. Therefore, these findings proved that by combining appropriate amount of Sr and Ag doping ions into S53P4 bioglass composition, cellular proliferation and antibacterial response could be stimulated, which could benefit patients who suffer from bacteria-infected bone defect diseases.
AB - The aim of this study is to investigate the response of cells and bacteria on Sr, Ag, and Sr + Ag doped S53P4 sol-gel bioglass. In this study, 3 mol% of SrO and 1 mol% of Ag2O were selected as doping for single and multiple doped S53P4 sol-gel bioglass. These doped specimens were denoted as BG, BG-3S, BG-1A, and BG-3S1A throughout the study. Cell study showed that the BG-3S1A specimen exhibited the highest proliferation of MC3T3-E1 osteoblast-like cells, ALP activity, and bone nodule formation in comparison with other specimens. Meanwhile, antibacterial study of the BG-3S1A specimen showed relatively similar antibacterial responses towards Escherichia coli and Staphylococcus aureus in comparison with the BG-1A specimen. Therefore, these findings proved that by combining appropriate amount of Sr and Ag doping ions into S53P4 bioglass composition, cellular proliferation and antibacterial response could be stimulated, which could benefit patients who suffer from bacteria-infected bone defect diseases.
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U2 - 10.1016/j.ceramint.2020.04.094
DO - 10.1016/j.ceramint.2020.04.094
M3 - Article
AN - SCOPUS:85083103759
SN - 0272-8842
VL - 46
SP - 17881
EP - 17890
JO - Ceramics International
JF - Ceramics International
IS - 11
ER -