Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats

Kengo Isegawa, Yoshitaka Hirooka, Takuya Kishi, Keiji Yasukawa, Hideo Utsumi, Kenji Sunagawa

Research output: Contribution to journalArticle

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Abstract

Abnormal elevation of blood pressure in early morning (rest-to-active phase) is suggested to cause cardiovascular events. We investigated whether azilsartan (AZL), a novel potent angiotensin receptor blocker, suppresses blood pressure elevation from the light-rest to dark-active phase in spontaneously hypertensive rats (SHRs). AZL has a sustained depressor effect around the rest-to-active phase in SHRs to a greater extent than candesartan (CAN), despite their similar depressor effects for over 24 h. AZL did not cause sympathoexcitation. These results suggest that AZL has a more sustained depressor effect than CAN around the rest-to-active phase in SHRs, and might have advantages for early morning hypertension.

Original languageEnglish
Pages (from-to)45-50
Number of pages6
JournalClinical and Experimental Hypertension
Volume37
Issue number1
DOIs
Publication statusPublished - Feb 1 2015

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Inbred SHR Rats
Blood Pressure
Angiotensin Receptor Antagonists
Hypertension
Light
azilsartan
candesartan

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology

Cite this

Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats. / Isegawa, Kengo; Hirooka, Yoshitaka; Kishi, Takuya; Yasukawa, Keiji; Utsumi, Hideo; Sunagawa, Kenji.

In: Clinical and Experimental Hypertension, Vol. 37, No. 1, 01.02.2015, p. 45-50.

Research output: Contribution to journalArticle

Isegawa, Kengo ; Hirooka, Yoshitaka ; Kishi, Takuya ; Yasukawa, Keiji ; Utsumi, Hideo ; Sunagawa, Kenji. / Benefit of azilsartan on blood pressure elevation around rest-to-active phase in spontaneously hypertensive rats. In: Clinical and Experimental Hypertension. 2015 ; Vol. 37, No. 1. pp. 45-50.
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