TY - JOUR
T1 - "Benifuuki" green tea, containing O-methylated EGCG, reduces serum low-density lipoprotein cholesterol and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B
T2 - A double-blind, placebo-controlled randomized trial
AU - Imbe, Hisashi
AU - Sano, Hiroyuki
AU - Miyawaki, Masahiro
AU - Fujisawa, Reiko
AU - Miyasato, Mai
AU - Nakatsuji, Fumihiko
AU - Haseda, Fumitaka
AU - Tanimoto, Keiji
AU - Terasaki, Jungo
AU - Maeda-Yamamoto, Mari
AU - Tachibana, Hirofumi
AU - Hanafusa, Toshiaki
N1 - Funding Information:
This work was supported by a grant from the Research Project on Development of Agricultural Products and Foods with Health-promoting Benefits (NARO), Japan (Grant No. A11 ). We thank the Osaka Medical College Health Science Clinic and Santa Maria Hospital for supporting in the recruitment of the study participants. We are indebted to Ms. Yukie Nakatsubo, Ms. Sayaka Ikeda, and Ms. Shinobu Mitsui (Osaka Medical College, Department of Internal Medicine (I)) for their devoted work consisting of the regular follow-ups of the study participants. We are also grateful to Ms. Yuki Shinoda (Asahi Soft Drinks, Co., Ltd., Tokyo, Japan) for providing us with the test tea extracts.
Publisher Copyright:
© 2016 The Authors.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Dyslipidaemia is a significant cardiovascular risk factor. Green tea catechins are known to have cholesterol-lowering effects. We investigated the beneficial effects of "Benifuuki," containing O-methylated catechin, on cardiovascular risk factors, specifically low-density lipoprotein (LDL) cholesterol levels. One-hundred fifty-five participants who met the inclusion criteria were divided into 3 groups: "Benifuuki," "Yabukita," or barley infusion drinkers. We evaluated the changes in parameters after 12 weeks. Serum LDL cholesterol levels in the "Benifuuki"-consuming participants were significantly lower than those in barley infusion-consuming participants without a green tea habit. Furthermore, the lectin-like oxidized low-density lipoprotein receptor-1 containing apolipoprotein B (LAB) levels in "Benifuuki" drinkers were significantly lower than those in the barley infusion group and the "Benifuuki" baseline LAB level. In participants without a green tea habit, "Benifuuki" significantly reduced the serum LDL cholesterol level and the LAB levels compared to those observed after barley infusion consumption.
AB - Dyslipidaemia is a significant cardiovascular risk factor. Green tea catechins are known to have cholesterol-lowering effects. We investigated the beneficial effects of "Benifuuki," containing O-methylated catechin, on cardiovascular risk factors, specifically low-density lipoprotein (LDL) cholesterol levels. One-hundred fifty-five participants who met the inclusion criteria were divided into 3 groups: "Benifuuki," "Yabukita," or barley infusion drinkers. We evaluated the changes in parameters after 12 weeks. Serum LDL cholesterol levels in the "Benifuuki"-consuming participants were significantly lower than those in barley infusion-consuming participants without a green tea habit. Furthermore, the lectin-like oxidized low-density lipoprotein receptor-1 containing apolipoprotein B (LAB) levels in "Benifuuki" drinkers were significantly lower than those in the barley infusion group and the "Benifuuki" baseline LAB level. In participants without a green tea habit, "Benifuuki" significantly reduced the serum LDL cholesterol level and the LAB levels compared to those observed after barley infusion consumption.
UR - http://www.scopus.com/inward/record.url?scp=84969793969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969793969&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2016.05.004
DO - 10.1016/j.jff.2016.05.004
M3 - Article
AN - SCOPUS:84969793969
SN - 1756-4646
VL - 25
SP - 25
EP - 37
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -