Benzodiazepine receptors in chronic cerebrovascular disease: Comparison with blood flow and metabolism

Masayuki Sasaki, Yuichi Ichiya, Yasuo Kuwabara, Tsuyoshi Yoshida, Toshimitsu Fukumura, Kouji Masuda

Research output: Contribution to journalArticle

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Abstract

The brain benzodiazepine (BZD) receptor distribution in patients with chronic cerebrovascular disease was assessed with 123I-iomazenil (IMZ) SPECT, and the findings were compared with the data for the cerebral blood flow (CBF) and cerebral metabolism. Methods: We examined nine patients with chronic cerebrovascular diseases, six patients with cerebral infarction and three with moyamoya disease. Iodine-123-IMZ SPECT images were obtained for 15 min, 3 hr after the administration of 167 or 222 MBq 123I-IMZ. In seven patients, the CBF and oxygen metabolism were measured by the 15O steady- state method. In two patients, the CBF and glucose metabolism were measured by 99mTc-HMPAO SPECT and 18F-fluoro-2-deoxy-D-glucose-PET, respectively. The brain was initially classified into 18 regions, and abnormalities in the BZD receptor distribution, CBF and cerebral metabolism were visually evaluated. The count ratio of lesion-to-contralateral normal region (L-to-C ratio) was then used for comparison. Results: In the core of the infarct, the 123I-IMZ uptake decreased (L-to-C ratios of the blood flow 0.42 ± 0.26; metabolism 0.45 ± 0.24; and 123I-IMZ uptake 0.46 ± 0.14). In the peri- infarct region, the 123I-IMZ uptake slightly decreased (L-to-C ratios of 0.81, 0.82 and 0.89, respectively). In the region of misery perfusion, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.73, 1.07 and 1.02, respectively). In the remote deafferentated areas in the ipsilateral cerebrum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.76 ± 0.10, 0.75 ± 0.04 and 0.98 ± 0.05, respectively). In the remote areas in the contralateral cerebellum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.84 ± 0.08, 0.85 ± 0.04 and 0.94 ± 0.05, respectively). Conclusion: The BZD receptor distribution, as measured by 1213I-IMZ SPECT, is not considered to reflect neuronal function, but it may reflect neuronal cell viability. Iodine-123-IMZ SPECT may, therefore, hold premise as a potential probe for neuronal damage.

Original languageEnglish
Pages (from-to)1693-1698
Number of pages6
JournalJournal of Nuclear Medicine
Volume38
Issue number11
Publication statusPublished - Nov 1 1997

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Cerebrovascular Disorders
GABA-A Receptors
Chronic Disease
Cerebrovascular Circulation
Single-Photon Emission-Computed Tomography
Iodine
iomazenil
Technetium Tc 99m Exametazime
Moyamoya Disease
Cerebral Infarction
Deoxyglucose
Brain
Cerebrum
Cerebellum
Blood Glucose
Cell Survival
Perfusion

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Sasaki, M., Ichiya, Y., Kuwabara, Y., Yoshida, T., Fukumura, T., & Masuda, K. (1997). Benzodiazepine receptors in chronic cerebrovascular disease: Comparison with blood flow and metabolism. Journal of Nuclear Medicine, 38(11), 1693-1698.

Benzodiazepine receptors in chronic cerebrovascular disease : Comparison with blood flow and metabolism. / Sasaki, Masayuki; Ichiya, Yuichi; Kuwabara, Yasuo; Yoshida, Tsuyoshi; Fukumura, Toshimitsu; Masuda, Kouji.

In: Journal of Nuclear Medicine, Vol. 38, No. 11, 01.11.1997, p. 1693-1698.

Research output: Contribution to journalArticle

Sasaki, M, Ichiya, Y, Kuwabara, Y, Yoshida, T, Fukumura, T & Masuda, K 1997, 'Benzodiazepine receptors in chronic cerebrovascular disease: Comparison with blood flow and metabolism', Journal of Nuclear Medicine, vol. 38, no. 11, pp. 1693-1698.
Sasaki, Masayuki ; Ichiya, Yuichi ; Kuwabara, Yasuo ; Yoshida, Tsuyoshi ; Fukumura, Toshimitsu ; Masuda, Kouji. / Benzodiazepine receptors in chronic cerebrovascular disease : Comparison with blood flow and metabolism. In: Journal of Nuclear Medicine. 1997 ; Vol. 38, No. 11. pp. 1693-1698.
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abstract = "The brain benzodiazepine (BZD) receptor distribution in patients with chronic cerebrovascular disease was assessed with 123I-iomazenil (IMZ) SPECT, and the findings were compared with the data for the cerebral blood flow (CBF) and cerebral metabolism. Methods: We examined nine patients with chronic cerebrovascular diseases, six patients with cerebral infarction and three with moyamoya disease. Iodine-123-IMZ SPECT images were obtained for 15 min, 3 hr after the administration of 167 or 222 MBq 123I-IMZ. In seven patients, the CBF and oxygen metabolism were measured by the 15O steady- state method. In two patients, the CBF and glucose metabolism were measured by 99mTc-HMPAO SPECT and 18F-fluoro-2-deoxy-D-glucose-PET, respectively. The brain was initially classified into 18 regions, and abnormalities in the BZD receptor distribution, CBF and cerebral metabolism were visually evaluated. The count ratio of lesion-to-contralateral normal region (L-to-C ratio) was then used for comparison. Results: In the core of the infarct, the 123I-IMZ uptake decreased (L-to-C ratios of the blood flow 0.42 ± 0.26; metabolism 0.45 ± 0.24; and 123I-IMZ uptake 0.46 ± 0.14). In the peri- infarct region, the 123I-IMZ uptake slightly decreased (L-to-C ratios of 0.81, 0.82 and 0.89, respectively). In the region of misery perfusion, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.73, 1.07 and 1.02, respectively). In the remote deafferentated areas in the ipsilateral cerebrum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.76 ± 0.10, 0.75 ± 0.04 and 0.98 ± 0.05, respectively). In the remote areas in the contralateral cerebellum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.84 ± 0.08, 0.85 ± 0.04 and 0.94 ± 0.05, respectively). Conclusion: The BZD receptor distribution, as measured by 1213I-IMZ SPECT, is not considered to reflect neuronal function, but it may reflect neuronal cell viability. Iodine-123-IMZ SPECT may, therefore, hold premise as a potential probe for neuronal damage.",
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AU - Fukumura, Toshimitsu

AU - Masuda, Kouji

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N2 - The brain benzodiazepine (BZD) receptor distribution in patients with chronic cerebrovascular disease was assessed with 123I-iomazenil (IMZ) SPECT, and the findings were compared with the data for the cerebral blood flow (CBF) and cerebral metabolism. Methods: We examined nine patients with chronic cerebrovascular diseases, six patients with cerebral infarction and three with moyamoya disease. Iodine-123-IMZ SPECT images were obtained for 15 min, 3 hr after the administration of 167 or 222 MBq 123I-IMZ. In seven patients, the CBF and oxygen metabolism were measured by the 15O steady- state method. In two patients, the CBF and glucose metabolism were measured by 99mTc-HMPAO SPECT and 18F-fluoro-2-deoxy-D-glucose-PET, respectively. The brain was initially classified into 18 regions, and abnormalities in the BZD receptor distribution, CBF and cerebral metabolism were visually evaluated. The count ratio of lesion-to-contralateral normal region (L-to-C ratio) was then used for comparison. Results: In the core of the infarct, the 123I-IMZ uptake decreased (L-to-C ratios of the blood flow 0.42 ± 0.26; metabolism 0.45 ± 0.24; and 123I-IMZ uptake 0.46 ± 0.14). In the peri- infarct region, the 123I-IMZ uptake slightly decreased (L-to-C ratios of 0.81, 0.82 and 0.89, respectively). In the region of misery perfusion, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.73, 1.07 and 1.02, respectively). In the remote deafferentated areas in the ipsilateral cerebrum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.76 ± 0.10, 0.75 ± 0.04 and 0.98 ± 0.05, respectively). In the remote areas in the contralateral cerebellum, the 123I-IMZ uptake was preserved (L-to-C ratios of 0.84 ± 0.08, 0.85 ± 0.04 and 0.94 ± 0.05, respectively). Conclusion: The BZD receptor distribution, as measured by 1213I-IMZ SPECT, is not considered to reflect neuronal function, but it may reflect neuronal cell viability. Iodine-123-IMZ SPECT may, therefore, hold premise as a potential probe for neuronal damage.

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