Benzyl protection of phenols under neutral conditions: Palladium-catalyzed benzylations of phenols

Ryoichi Kuwano, Hiroki Kusano

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Abstract

Benzyl protection of phenols under neutral conditions was achieved by using a Pd(n3-C3H5)Cp-DPEphos catalyst. The palladium catalyst efficiently converted aryl benzyl carbonates into benzyl-protected phenols through the decarboxylative etherification. Alternatively, the nucleophilic substitution of benzyl methyl carbonates with phenols proceeded In the presence of the catalyst, yielding aryl benzyl ethers.

Original languageEnglish
Pages (from-to)1979-1982
Number of pages4
JournalOrganic Letters
Volume10
Issue number10
DOIs
Publication statusPublished - May 15 2008

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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