Abstract
Bicarbonate umbrella is a cell protective function from cytotoxic molecules by extracellular secretion of bicarbonate. Small bile ducts use this function to protect from hydrophobic bile acids, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs). On the other hand, primary biliary cholangitis (PBC) whose head of issue is characterized by the destruction of small bile ducts with the dysfunction of the bicarbonate umbrella as Cl-/HCO3- exchanger anion exchanger 2 (AE2) activation. PBC has two features; an organ-specific autoimmune disease and a cytopathic biliary disease due to bile exposure that has strong cytotoxicity. Thus, bile ducts of PBC are exposed to two types of bile acids; hydrophilic and cytoprotective ursodeoxycholic acid (UDCA) and hyrophobic and cytotoxic bile acids. UDCA is effective to protect bile exposure in the early phase of the disease, and UDCA is not so effective in the advanced phase where abnormal acquired immunity has central roles for destruction of the small bile ducts.
| Original language | English |
|---|---|
| Title of host publication | Pathology of the Bile Duct |
| Publisher | Springer Singapore |
| Pages | 19-24 |
| Number of pages | 6 |
| ISBN (Electronic) | 9789811035005 |
| ISBN (Print) | 9789811034992 |
| DOIs | |
| Publication status | Published - May 26 2017 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Bicarbonate umbrella and its distribution of the bile duct. / Shimoda, Shinji.
Pathology of the Bile Duct. Springer Singapore, 2017. p. 19-24.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Bicarbonate umbrella and its distribution of the bile duct
AU - Shimoda, Shinji
PY - 2017/5/26
Y1 - 2017/5/26
N2 - Bicarbonate umbrella is a cell protective function from cytotoxic molecules by extracellular secretion of bicarbonate. Small bile ducts use this function to protect from hydrophobic bile acids, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs). On the other hand, primary biliary cholangitis (PBC) whose head of issue is characterized by the destruction of small bile ducts with the dysfunction of the bicarbonate umbrella as Cl-/HCO3- exchanger anion exchanger 2 (AE2) activation. PBC has two features; an organ-specific autoimmune disease and a cytopathic biliary disease due to bile exposure that has strong cytotoxicity. Thus, bile ducts of PBC are exposed to two types of bile acids; hydrophilic and cytoprotective ursodeoxycholic acid (UDCA) and hyrophobic and cytotoxic bile acids. UDCA is effective to protect bile exposure in the early phase of the disease, and UDCA is not so effective in the advanced phase where abnormal acquired immunity has central roles for destruction of the small bile ducts.
AB - Bicarbonate umbrella is a cell protective function from cytotoxic molecules by extracellular secretion of bicarbonate. Small bile ducts use this function to protect from hydrophobic bile acids, damage-associated molecular patterns (DAMPs), and pathogen-associated molecular patterns (PAMPs). On the other hand, primary biliary cholangitis (PBC) whose head of issue is characterized by the destruction of small bile ducts with the dysfunction of the bicarbonate umbrella as Cl-/HCO3- exchanger anion exchanger 2 (AE2) activation. PBC has two features; an organ-specific autoimmune disease and a cytopathic biliary disease due to bile exposure that has strong cytotoxicity. Thus, bile ducts of PBC are exposed to two types of bile acids; hydrophilic and cytoprotective ursodeoxycholic acid (UDCA) and hyrophobic and cytotoxic bile acids. UDCA is effective to protect bile exposure in the early phase of the disease, and UDCA is not so effective in the advanced phase where abnormal acquired immunity has central roles for destruction of the small bile ducts.
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U2 - 10.1007/978-981-10-3500-5_2
DO - 10.1007/978-981-10-3500-5_2
M3 - Chapter
AN - SCOPUS:85033345025
SN - 9789811034992
SP - 19
EP - 24
BT - Pathology of the Bile Duct
PB - Springer Singapore
ER -